RND2 Rho Family GTPase
Atypical Rho GTPase Involved in Neuronal Development and Cancer
Gene Information Card
| Symbol | RND2 |
|---|---|
| Full Name | Rho family GTPase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 8153 ncbi.nlm.nih.gov/gene/8153 |
| Ensembl ID | ENSG00000108848 |
| UniProt ID | P52198 |
| OMIM ID | 601555 |
| HGNC ID | 1831 |
| Aliases | RhoN, ARHN, Rho7 |
Description
RND2 (Rho family GTPase 2) encodes a member of the Rho GTPase family, specifically the Rnd subfamily. Unlike classical Rho GTPases, Rnd proteins lack intrinsic GTPase activity and are constitutively active. RND2 is involved in actin cytoskeleton reorganization, cell migration, and neurite outgrowth. It is highly expressed in the brain and plays a role in neuronal development and plasticity. Altered expression has been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | RND2 overexpression promotes cell migration and invasion via cytoskeletal remodeling | PMID: 25636844 |
| Breast Cancer | RND2 downregulation correlates with poor prognosis and increased metastasis | PMID: 27150010 |
| Prostate Cancer | RND2 expression is reduced and associated with tumor progression | PMID: 21804532 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Testis | 4.3 | Medium |
| Lung | 2.1 | Low |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| U87MG (glioblastoma) | 8.7 | High expression |
| MCF7 (breast cancer) | 1.3 | Low expression |
| PC3 (prostate cancer) | 0.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.172C>T (p.Arg58Cys) | Missense | <0.1% | Unknown functional effect |
| c.301G>A (p.Glu101Lys) | Missense | <0.1% | Predicted benign |
| c.425_426insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.425_426insA) are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Rho GTPase cycle (Reactome: R-HSA-194840)
• Signaling by Rho family GTPases (Reactome: R-HSA-194315)
Protein Summary
RND2 is a 225-amino acid protein belonging to the Rnd subfamily of Rho GTPases. It lacks intrinsic GTPase activity and remains constitutively bound to GTP. The protein regulates actin cytoskeleton dynamics, promoting cell rounding and inhibiting stress fiber formation. RND2 is critical for neuronal development, including neurite outgrowth and axon guidance. Its expression is tightly regulated, and dysregulation contributes to cancer cell migration and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RND2 Knockout HEK293 Cell Line | EDJ-KQ6178 | Human | 8153 | Details Get a Quote |
| RND2 Knockout HCT 116 Cell Line | EDJ-KQ30002 | Human | 8153 | Details Get a Quote |
| RND2 Knockout HeLa Cell Line | EDJ-KQ54826 | Human | 8153 | Details Get a Quote |
| RND2 Knockout A-549 Cell Line | EDJ-KQ63317 | Human | 8153 | Details Get a Quote |
