RNASE7: Ribonuclease A Family Member 7
Antimicrobial RNase with Key Roles in Innate Immunity and Host Defense
Gene Information Card
| Symbol | RNASE7 |
|---|---|
| Full Name | Ribonuclease A Family Member 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 84659 ncbi.nlm.nih.gov/gene/84659 |
| Ensembl ID | ENSG00000165799 |
| UniProt ID | Q9H1E1 |
| OMIM ID | 612484 |
| HGNC ID | 10057 |
| Aliases | RNase 7, ribonuclease 7, antimicrobial RNase |
Description
RNASE7 encodes ribonuclease 7, a member of the RNase A superfamily. This secreted protein exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and viruses, contributing to innate immune defense on epithelial surfaces, particularly in skin, urinary tract, and respiratory tract. It possesses ribonucleolytic activity and is induced by inflammatory stimuli.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Psoriasis | Overexpression of RNASE7 in psoriatic skin lesions contributes to altered antimicrobial defense and inflammation. | NCBI Gene, OMIM |
| Urinary Tract Infection (UTI) | RNASE7 is highly expressed in urothelial cells and its antimicrobial activity helps prevent bacterial colonization. Reduced expression may increase susceptibility. | NCBI Gene, PubMed |
| Atopic Dermatitis | Dysregulated RNASE7 expression in skin lesions may impair barrier function and antimicrobial defense. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 78.2 | High |
| Esophagus | 45.1 | Medium |
| Lung | 12.3 | Low |
| Kidney | 8.9 | Low |
| Urinary Bladder | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocyte) | 85.0 | High baseline expression |
| A549 (lung epithelial) | 22.5 | Inducible by IL-1β |
| HEK293 (embryonic kidney) | 5.0 | Low expression |
| UROtsa (urothelial) | 40.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.214C>T (p.Arg72Cys) | missense | <0.01% | May affect disulfide bond formation and RNase activity |
Mutation functional classification
Loss of Function (LOF)
Mutations disrupting catalytic residues (e.g., His15, His119) or disulfide bonds likely impair ribonucleolytic and antimicrobial activity.
Gain of Function (GOF)
Not reported; no known activating mutations.
Dominant Negative (DN)
Not reported; RNASE7 functions as a monomeric secreted protein.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Antimicrobial peptides (Reactome: R-HSA-6803157)
• Innate Immune System (Reactome: R-HSA-168249)
Protein Summary
Ribonuclease 7 (RNase 7) is a 156-amino acid secreted protein with a signal peptide (residues 1-28) and a mature chain (29-156). It contains the conserved RNase A catalytic triad (His15, Lys41, His119) and three disulfide bonds. The protein exhibits potent antimicrobial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Escherichia coli, as well as Candida albicans. Its expression is upregulated by IL-1β, TNF-α, and bacterial components via NF-κB and MAPK pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNASE7 Knockout HEK293 Cell Line | EDJ-KQ10150 | Human | 84659 | Details Get a Quote |
| RNASE7 Knockout HeLa Cell Line | EDJ-KQ57635 | Human | 84659 | Details Get a Quote |
| RNASE7 Knockout A-549 Cell Line | EDJ-KQ66132 | Human | 84659 | Details Get a Quote |
| RNASE7 Knockout HCT 116 Cell Line | EDJ-KQ74558 | Human | 84659 | Details Get a Quote |
