RNASE6: Ribonuclease A Family Member 6
Antimicrobial RNase with roles in innate immunity and inflammation
Gene Information Card
| Symbol | RNASE6 |
|---|---|
| Full Name | ribonuclease A family member 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 6039 ncbi.nlm.nih.gov/gene/6039 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q93091 |
| OMIM ID | 601981 |
| HGNC ID | 10047 |
| Aliases | RNase6, RNase k6, RAE-1 |
Description
RNASE6 (ribonuclease A family member 6) encodes a secreted ribonuclease belonging to the RNase A superfamily. The protein exhibits antimicrobial activity against bacteria and viruses, and is involved in innate immune responses. It is expressed in various tissues, particularly in the respiratory and gastrointestinal tracts, and is upregulated during inflammation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | Altered RNASE6 expression may contribute to mucosal inflammation | PMID: 25657065 |
| Chronic rhinosinusitis | Upregulation of RNASE6 in nasal epithelium during inflammation | PMID: 28472622 |
| Bacterial infections | Antimicrobial activity against Gram-positive and Gram-negative bacteria | PMID: 23687358 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Small intestine | 8.3 | Medium |
| Colon | 7.1 | Medium |
| Spleen | 6.8 | Low |
| Bone marrow | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 15.2 | High expression |
| Caco-2 (colorectal adenocarcinoma) | 9.8 | Moderate expression |
| THP-1 (monocytic leukemia) | 7.4 | Moderate expression |
| HeLa (cervical carcinoma) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown effect |
| c.124G>A | missense | <0.01% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ribonuclease A family pathway (Reactome: R-HSA-6806667)
• Innate immune system (Reactome: R-HSA-168249)
Protein Summary
RNASE6 is a secreted ribonuclease of 150 amino acids (17.5 kDa) with a signal peptide (residues 1-28). It contains the conserved catalytic residues His12, His119, and Lys41 typical of RNase A family members. The protein has broad-spectrum antimicrobial activity, targeting bacterial and viral pathogens. It is expressed in epithelial cells and upregulated by inflammatory stimuli such as IL-1β and TNF-α.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNASE6 Knockout HEK293 Cell Line | EDJ-KQ5676 | Human | 6039 | Details Get a Quote |
| RNASE6 Knockout HeLa Cell Line | EDJ-KQ54332 | Human | 6039 | Details Get a Quote |
| RNASE6 Knockout A-549 Cell Line | EDJ-KQ62825 | Human | 6039 | Details Get a Quote |
| RNASE6 Knockout HCT 116 Cell Line | EDJ-KQ71290 | Human | 6039 | Details Get a Quote |
