RNASE11
Ribonuclease A Family Member 11 (Inactive)
Gene Information Card
| Symbol | RNASE11 |
|---|---|
| Full Name | ribonuclease A family member 11 (inactive) |
| Gene Type | protein-coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 122651 ncbi.nlm.nih.gov/gene/122651 |
| Ensembl ID | ENSG00000100811 |
| UniProt ID | Q8TAA1 |
| OMIM ID | 612981 |
| HGNC ID | 19872 |
| Aliases | RNASE11, ribonuclease 11 |
Description
RNASE11 is a member of the ribonuclease A superfamily. The encoded protein is predicted to be catalytically inactive due to the absence of key active-site residues. It is primarily expressed in the testis and may play a role in male reproductive biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.1 | Medium |
| Fallopian tube | 0.4 | Not detected |
| Other tissues | <0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low expression |
| HeLa | 0.1 | Low expression |
| K562 | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No somatic mutations reported in COSMIC | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • ribonuclease activity (GO:0004540) | • endonuclease activity (GO:0004519) |
Protein Summary
The RNASE11 protein is a member of the ribonuclease A family but lacks catalytic activity due to substitutions in the active site. It is predominantly expressed in the testis, suggesting a role in spermatogenesis or reproductive function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNASE11 Knockout HEK293 Cell Line | EDJ-KQ8160 | Human | 122651 | Details Get a Quote |
| RNASE11 Knockout HeLa Cell Line | EDJ-KQ58101 | Human | 122651 | Details Get a Quote |
| RNASE11 Knockout A-549 Cell Line | EDJ-KQ66589 | Human | 122651 | Details Get a Quote |
| RNASE11 Knockout HCT 116 Cell Line | EDJ-KQ75005 | Human | 122651 | Details Get a Quote |
