RNASE10: Ribonuclease A Family Member 10
A secreted ribonuclease with potential roles in male reproductive biology and innate immunity.
Gene Information Card
| Symbol | RNASE10 |
|---|---|
| Full Name | Ribonuclease A Family Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 338879 ncbi.nlm.nih.gov/gene/338879 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q5GAN3 |
| OMIM ID | 612944 |
| HGNC ID | 19857 |
| Aliases | RAH1, RNase10, RNASE10P |
Description
RNASE10 encodes a member of the ribonuclease A superfamily. The encoded protein is a secreted ribonuclease with broad-spectrum antimicrobial activity and is highly expressed in the male reproductive tract, particularly in the epididymis. It is thought to play a role in host defense and sperm maturation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | Altered expression or activity may impair sperm function and fertility | Low expression in epididymis associated with asthenozoospermia (PMID: 23555205) |
| Bacterial infections | Antimicrobial activity against Gram-positive and Gram-negative bacteria | Direct bactericidal effect demonstrated in vitro (PMID: 23376485) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Epididymis | 125.4 | High |
| Testis | 12.3 | Medium |
| Prostate | 5.6 | Low |
| Kidney | 1.2 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.8 | Low expression |
| HEK293 | 1.1 | Low expression |
| HepG2 | 0.3 | Not detected |
| MCF7 | 0.6 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon, predicted loss of function |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | May disrupt disulfide bond, reduced RNase activity |
Mutation functional classification
Loss of Function (LOF)
Mutations that abolish catalytic activity or secretion are predicted to impair antimicrobial defense and sperm function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ribonuclease A family pathway (Reactome: R-HSA-6806667)
Protein Summary
RNASE10 is a 25.5 kDa secreted ribonuclease belonging to the RNase A superfamily. It contains a signal peptide and a conserved catalytic domain with His-Lys-His motif. The protein exhibits broad-spectrum antimicrobial activity and is predominantly expressed in the epididymis, where it may contribute to sperm maturation and protection against urogenital pathogens.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNASE10 Knockout HEK293 Cell Line | EDJ-KQ14324 | Human | 338879 | Details Get a Quote |
| RNASE10 Knockout HeLa Cell Line | EDJ-KQ59628 | Human | 338879 | Details Get a Quote |
| RNASE10 Knockout A-549 Cell Line | EDJ-KQ68094 | Human | 338879 | Details Get a Quote |
| RNASE10 Knockout HCT 116 Cell Line | EDJ-KQ76469 | Human | 338879 | Details Get a Quote |
