RIDA Gene (Reactive Intermediate Imine Deaminase A Homolog)
Functional and clinical insights into the RIDA gene, encoding a p53-inducible regulator of reactive intermediate deamination.
Gene Information Card
| Symbol | RIDA |
|---|---|
| Full Name | Reactive Intermediate Imine Deaminase A Homolog |
| Gene Type | Protein coding |
| Chromosomal Location | 2q24.2 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000115977 |
| UniProt ID | P52758 |
| OMIM ID | 191170 |
| HGNC ID | HGNC:10059 |
| Aliases | HRG2, UK114, p14.5, HPBRII-7 |
Description
RIDA (reactive intermediate imine deaminase A homolog) encodes a member of the YjgF/YER057c/UK114 family of proteins. The protein is a p53-inducible regulator that catalyzes the deamination of reactive imine intermediates, thereby preventing the accumulation of toxic metabolites. It is involved in cellular stress responses, amino acid metabolism, and may play a role in tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Downregulation of RIDA may impair metabolic detoxification, contributing to tumor progression. | NCBI Gene, OMIM |
| Colorectal cancer | Reduced expression associated with poor prognosis; p53-dependent regulation. | NCBI Gene, COSMIC |
| Breast cancer | Altered expression linked to p53 mutation status. | COSMIC, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 9.8 | Medium |
| Heart | 6.3 | Low |
| Brain | 4.1 | Low |
| Lung | 3.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.2 | Hepatocellular carcinoma cell line |
| HEK293 | 8.5 | Embryonic kidney cells |
| MCF7 | 5.1 | Breast cancer cell line |
| A549 | 4.3 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1?; potential loss of start codon |
| c.104C>T | Missense | <0.01% | p.Thr35Met; uncertain significance |
| c.205G>A | Missense | <0.01% | p.Glu69Lys; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • deaminase activity (GO:0019239) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) | • metabolic process (GO:0008152) |
| • identical protein binding (GO:0042802) |
Pathways
• Amino acid metabolism
• p53 signaling pathway (indirect)
Protein Summary
The RIDA protein (UniProt P52758) is a homotrimeric enzyme that catalyzes the deamination of reactive imine intermediates formed during amino acid metabolism. It is highly expressed in liver and kidney, and its expression is regulated by p53. The protein has a molecular mass of approximately 14.5 kDa and belongs to the YjgF/YER057c/UK114 family. Structural studies indicate a conserved active site involved in substrate binding and catalysis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RIDA Knockout HEK293 Cell Line | EDJ-KQ6973 | Human | 10247 | Details Get a Quote |
| RIDA Knockout A-549 Cell Line | EDJ-KQ31668 | Human | 10247 | Details Get a Quote |
| RIDA Knockout HCT 116 Cell Line | EDJ-KQ31669 | Human | 10247 | Details Get a Quote |
| RIDA Knockout HeLa Cell Line | EDJ-KQ31670 | Human | 10247 | Details Get a Quote |
