RHOQ (Ras Homolog Family Member Q)
A small GTPase involved in cytoskeletal dynamics, cell migration, and vesicle trafficking.
Gene Information Card
| Symbol | RHOQ |
|---|---|
| Full Name | Ras homolog family member Q |
| Gene Type | protein-coding |
| Chromosomal Location | 2p21 |
| NCBI Gene ID | 23433 ncbi.nlm.nih.gov/gene/23433 |
| Ensembl ID | ENSG00000119729 |
| UniProt ID | P17081 |
| OMIM ID | 605723 |
| HGNC ID | 17736 |
| Aliases | TC10, TC10A, RASL7A |
Description
RHOQ (Ras homolog family member Q) encodes a member of the Rho family of small GTPases. The protein, also known as TC10, regulates cytoskeletal reorganization, cell polarity, vesicle trafficking, and insulin-stimulated glucose uptake. It cycles between an active GTP-bound and inactive GDP-bound state, acting as a molecular switch in signal transduction pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 diabetes | Impaired insulin-stimulated GLUT4 translocation due to altered RHOQ signaling | PMID: 12556452 |
| Breast cancer | Overexpression of RHOQ promotes cell migration and invasion via cytoskeletal remodeling | PMID: 22926524 |
| Ovarian cancer | RHOQ upregulation correlates with poor prognosis and enhanced metastatic potential | PMID: 25636847 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Skeletal muscle | 8.3 | Low |
| Brain | 6.1 | Low |
| Heart | 4.7 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| MCF7 | 10.8 | Breast cancer cell line |
| HepG2 | 3.4 | Hepatocellular carcinoma cell line |
| SK-OV-3 | 18.6 | Ovarian cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.173C>T (p.Thr58Ile) | Missense | <0.1% | Altered GTP binding affinity |
| c.344G>A (p.Arg115His) | Missense | <0.1% | Reduced GTPase activity |
| c.458A>G (p.Asn153Ser) | Missense | <0.1% | Impaired membrane localization |
Mutation functional classification
Loss of Function (LOF)
Mutations that impair GTP binding or hydrolysis (e.g., p.Thr58Ile) reduce downstream signaling.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in RHOQ.
Dominant Negative (DN)
Mutations that lock the protein in a GDP-bound state (e.g., p.Thr58Ile) can act as dominant-negative inhibitors.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Insulin signaling pathway (Reactome: R-HSA-74752)
• RHO GTPase cycle (Reactome: R-HSA-9012999)
• Signaling by Rho family GTPases (Reactome: R-HSA-194315)
Protein Summary
RHOQ (TC10) is a 205-amino-acid small GTPase that localizes to the plasma membrane and endosomes. It regulates actin dynamics, cell adhesion, and vesicle trafficking. In adipocytes and muscle cells, RHOQ mediates insulin-stimulated GLUT4 translocation, linking it to glucose homeostasis. Aberrant expression or mutation of RHOQ is associated with cancer progression and metabolic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RHOQ Knockout HEK293 Cell Line | EDJ-KQ51105 | Human | 23433 | Details Get a Quote |
| RHOQ Knockout HeLa Cell Line | EDJ-KQ55737 | Human | 23433 | Details Get a Quote |
| RHOQ Knockout A-549 Cell Line | EDJ-KQ64235 | Human | 23433 | Details Get a Quote |
| RHOQ Knockout HCT 116 Cell Line | EDJ-KQ72680 | Human | 23433 | Details Get a Quote |
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