RHOB Gene
Ras Homolog Family Member B
Gene Information Card
| Symbol | RHOB |
|---|---|
| Full Name | Ras Homolog Family Member B |
| Gene Type | Protein coding |
| Chromosomal Location | 2p24.1 |
| NCBI Gene ID | 388 ncbi.nlm.nih.gov/gene/388 |
| Ensembl ID | ENSG00000143878 |
| UniProt ID | P62745 |
| OMIM ID | 165370 |
| HGNC ID | 10014 |
| Aliases | ARHB, RHOB, RHOH6 |
Description
RHOB (Ras Homolog Family Member B) is a protein-coding gene that belongs to the Rho family of small GTPases. It regulates cytoskeletal dynamics, cell adhesion, migration, and intracellular trafficking. RHOB is involved in stress responses, apoptosis, and tumor suppression, with altered expression linked to various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered RHOB expression affects cell proliferation, migration, and invasion via Rho signaling pathways. | NCBI Gene, COSMIC |
| Cardiovascular disease | RHOB modulates vascular smooth muscle cell migration and neointimal formation. | NCBI Gene, UniProt |
| Neurodegenerative disorders | RHOB influences neuronal morphology and synaptic function. | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Heart | 10.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 11.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | Cervical adenocarcinoma |
| A549 | 14.2 | Lung carcinoma |
| HEK 293 | 16.0 | Embryonic kidney |
| MCF7 | 9.8 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123G>A | Missense | <0.1% | Unknown functional effect |
| c.456C>T | Nonsense | <0.1% | Predicted loss of function |
| c.789_790insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants likely lead to truncated protein and loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not documented for RHOB.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activity | • Protein binding |
| • Signal transduction | • Cell migration |
| • Actin cytoskeleton organization | • Apoptotic process |
Pathways
• Rho GTPase cycle
• Signaling by Rho family GTPases
• Regulation of actin cytoskeleton
• Apoptosis
Protein Summary
RHOB encodes a 196-amino acid protein (21 kDa) that localizes to endosomes and the plasma membrane. It cycles between active GTP-bound and inactive GDP-bound states, regulating actin dynamics, vesicular trafficking, and cell survival. RHOB is induced by cellular stress and acts as a tumor suppressor in many contexts.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RHOB Knockout HEK293 Cell Line | EDJ-KQ4084 | Human | 388 | Details Get a Quote |
| RHOBTB1 Knockout HEK293 Cell Line | EDJ-KQ6800 | Human | 9886 | Details Get a Quote |
| RHOBTB3 Knockout HEK293 Cell Line | EDJ-KQ7685 | Human | 22836 | Details Get a Quote |
| RHOBTB2 Knockout HEK293 Cell Line | EDJ-KQ7903 | Human | 23221 | Details Get a Quote |
| RHOBTB3 Knockout A-549 Cell Line | EDJ-KQ33045 | Human | 22836 | Details Get a Quote |
| RHOBTB3 Knockout HCT 116 Cell Line | EDJ-KQ33046 | Human | 22836 | Details Get a Quote |
| RHOBTB3 Knockout HeLa Cell Line | EDJ-KQ33047 | Human | 22836 | Details Get a Quote |
| RHOB Knockout A-549 Cell Line | EDJ-KQ26456 | Human | 388 | Details Get a Quote |
| RHOB Knockout HCT 116 Cell Line | EDJ-KQ26457 | Human | 388 | Details Get a Quote |
| RHOB Knockout HeLa Cell Line | EDJ-KQ26458 | Human | 388 | Details Get a Quote |
| RHOBTB1 Knockout A-549 Cell Line | EDJ-KQ31294 | Human | 9886 | Details Get a Quote |
| RHOBTB1 Knockout HCT 116 Cell Line | EDJ-KQ31295 | Human | 9886 | Details Get a Quote |
| RHOBTB1 Knockout HeLa Cell Line | EDJ-KQ31296 | Human | 9886 | Details Get a Quote |
| RHOBTB2 Knockout A-549 Cell Line | EDJ-KQ33511 | Human | 23221 | Details Get a Quote |
| RHOBTB2 Knockout HCT 116 Cell Line | EDJ-KQ33512 | Human | 23221 | Details Get a Quote |
Displaying Records 1 To 15 Of 16 Records
