RGS7BP
Regulator of G Protein Signaling 7 Binding Protein
Gene Information Card
| Symbol | RGS7BP |
|---|---|
| Full Name | Regulator of G Protein Signaling 7 Binding Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 5q12.3 |
| NCBI Gene ID | 401190 ncbi.nlm.nih.gov/gene/401190 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q6ZV29 |
| OMIM ID | 615074 |
| HGNC ID | 29526 |
| Aliases | RGS7BP, FLJ32709, RGS7-binding protein |
Description
RGS7BP (Regulator of G Protein Signaling 7 Binding Protein) encodes a protein that binds to RGS7, modulating G protein-coupled receptor signaling. It is involved in the regulation of signal transduction pathways, particularly in neuronal tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not applicable | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 3.2 | Low |
| Liver | 1.1 | Not detected |
| Kidney | 2.8 | Low |
| Testis | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.0 | Moderate expression |
| SH-SY5Y | 15.3 | High expression |
| HeLa | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • protein binding |
| • cytoplasm |
Pathways
• G alpha (i) signaling events
• RGS regulation of G protein signaling
Protein Summary
The RGS7BP protein is a 313-amino acid polypeptide that interacts with RGS7, enhancing its ability to regulate G protein signaling. It is predominantly expressed in the brain and testis, suggesting a role in neuronal signal modulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RGS7BP Knockout HEK293 Cell Line | EDJ-KQ11625 | Human | 401190 | Details Get a Quote |
| RGS7BP Knockout HeLa Cell Line | EDJ-KQ60290 | Human | 401190 | Details Get a Quote |
| RGS7BP Knockout A-549 Cell Line | EDJ-KQ68755 | Human | 401190 | Details Get a Quote |
| RGS7BP Knockout HCT 116 Cell Line | EDJ-KQ77121 | Human | 401190 | Details Get a Quote |
