RGS21: Regulator of G Protein Signaling 21
A member of the RGS protein family involved in modulating G protein-coupled receptor signaling.
Gene Information Card
| Symbol | RGS21 |
|---|---|
| Full Name | Regulator of G Protein Signaling 21 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q31.2 |
| NCBI Gene ID | 100170841 ncbi.nlm.nih.gov/gene/100170841 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | Q5VZP5 |
| OMIM ID | 615880 |
| HGNC ID | 33793 |
| Aliases | RGS21 |
Description
RGS21 (Regulator of G Protein Signaling 21) is a protein-coding gene belonging to the RGS (Regulator of G Protein Signaling) family. RGS proteins act as GTPase-activating proteins (GAPs) for G protein alpha subunits, accelerating the termination of G protein-coupled receptor (GPCR) signaling. RGS21 is specifically expressed in taste tissues and is involved in the modulation of bitter taste transduction. It is also expressed in other tissues and may play roles in immune and neuronal signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | Not available | High (specific) |
| Testis | Not available | Moderate |
| Brain | Not available | Low |
| Lung | Not available | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | Not available | Used in functional studies |
| Taste receptor cells | Not available | Endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in human disease.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • G protein-coupled receptor signaling pathway |
| • regulation of G protein-coupled receptor signaling pathway | • cytoplasm |
Pathways
• G alpha (i) signaling events
• GPCR downstream signaling
Protein Summary
RGS21 is a 210-amino acid protein containing a conserved RGS domain. It functions as a GTPase-activating protein (GAP) for G protein alpha subunits, particularly Gαi and Gαq, thereby negatively regulating GPCR signaling. RGS21 is highly expressed in taste buds and modulates bitter taste perception. Its expression in other tissues suggests broader roles in signal transduction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RGS21 Knockout HEK293 Cell Line | EDJ-KQ15057 | Human | 431704 | Details Get a Quote |
| RGS21 Knockout HeLa Cell Line | EDJ-KQ60369 | Human | 431704 | Details Get a Quote |
| RGS21 Knockout A-549 Cell Line | EDJ-KQ68837 | Human | 431704 | Details Get a Quote |
| RGS21 Knockout HCT 116 Cell Line | EDJ-KQ77200 | Human | 431704 | Details Get a Quote |
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