RGS13: Regulator of G Protein Signaling 13
A key modulator of G protein-coupled receptor signaling in immune cells and cancer
Gene Information Card
| Symbol | RGS13 |
|---|---|
| Full Name | Regulator of G Protein Signaling 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q31.2 |
| NCBI Gene ID | 6003 ncbi.nlm.nih.gov/gene/6003 |
| Ensembl ID | ENSG00000143294 |
| UniProt ID | O14921 |
| OMIM ID | 607190 |
| HGNC ID | 9995 |
| Aliases | RGS13, regulator of G-protein signaling 13 |
Description
RGS13 (Regulator of G Protein Signaling 13) is a member of the regulator of G protein signaling (RGS) family. It acts as a GTPase-activating protein (GAP) for Gα subunits of heterotrimeric G proteins, accelerating the termination of G protein-coupled receptor (GPCR) signaling. RGS13 is predominantly expressed in lymphoid tissues, particularly in germinal center B cells, and plays a role in immune cell activation, migration, and differentiation. It has been implicated in allergic inflammation, autoimmune diseases, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Allergic rhinitis | RGS13 modulates mast cell and basophil degranulation via GPCR signaling; altered expression linked to increased histamine release. | NCBI Gene, OMIM |
| Asthma | RGS13 expression is reduced in airway epithelial cells, leading to enhanced G protein signaling and bronchoconstriction. | NCBI Gene, OMIM |
| B-cell lymphoma | RGS13 is overexpressed in germinal center B-cell lymphomas; may promote cell survival and proliferation through dysregulated GPCR signaling. | COSMIC, NCBI Gene |
| Breast cancer | RGS13 expression is altered in breast cancer tissues; potential role in tumor progression via modulation of chemokine signaling. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Tonsil | 15.2 | Medium |
| Bone marrow | 4.3 | Low |
| Lung | 1.2 | Low |
| Breast | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Raji (Burkitt lymphoma) | 18.5 | B-cell line; high expression |
| Daudi (Burkitt lymphoma) | 16.2 | B-cell line; high expression |
| Jurkat (T-cell leukemia) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 0.5 | Not detected |
| MCF7 (breast cancer) | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.157C>T (p.Arg53Cys) | Missense | <0.1% | Altered GAP activity; reduced ability to terminate G protein signaling |
| c.304G>A (p.Gly102Ser) | Missense | <0.1% | Unknown functional effect; reported in COSMIC |
| c.421_423del (p.Lys141del) | In-frame deletion | <0.1% | Potential loss of function; observed in lymphoma samples |
Mutation functional classification
Loss of Function (LOF)
Mutations that impair GAP activity (e.g., p.Arg53Cys) lead to prolonged GPCR signaling, potentially contributing to immune dysregulation.
Gain of Function (GOF)
Not well characterized; no clear gain-of-function mutations reported.
Dominant Negative (DN)
Not reported for RGS13.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • G protein-coupled receptor signaling pathway |
| • negative regulation of signal transduction | • regulation of G protein-coupled receptor signaling pathway |
| • cytoplasm | • nucleus |
Pathways
• G alpha (i) signaling events
• GPCR downstream signaling
• RGS family in immune regulation
Protein Summary
RGS13 is a 159-amino acid protein containing a conserved RGS domain that mediates its GAP activity. It accelerates the hydrolysis of GTP bound to Gαi and Gαq subunits, thereby terminating GPCR signaling. RGS13 is highly expressed in germinal center B cells and modulates chemokine receptor signaling, affecting B cell migration and antibody production. Its dysregulation is associated with allergic diseases and lymphomas.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RGS13 Knockout HEK293 Cell Line | EDJ-KQ5668 | Human | 6003 | Details Get a Quote |
| RGS13 Knockout HeLa Cell Line | EDJ-KQ54320 | Human | 6003 | Details Get a Quote |
| RGS13 Knockout A-549 Cell Line | EDJ-KQ62814 | Human | 6003 | Details Get a Quote |
| RGS13 Knockout HCT 116 Cell Line | EDJ-KQ71279 | Human | 6003 | Details Get a Quote |
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