RGPD3: RANBP2-like and GRIP domain-containing protein 3
A member of the RANBP2 family with potential roles in nuclear transport and cellular signaling
Gene Information Card
| Symbol | RGPD3 |
|---|---|
| Full Name | RANBP2-like and GRIP domain-containing protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q13 |
| NCBI Gene ID | 400931 ncbi.nlm.nih.gov/gene/400931 |
| Ensembl ID | ENSG00000185499 |
| UniProt ID | Q9H6Z4 |
| OMIM ID | 617142 |
| HGNC ID | 26710 |
| Aliases | RANBP2L3, RANBP2-like 3, GRIP domain-containing 3 |
Description
RGPD3 (RANBP2-like and GRIP domain-containing protein 3) is a protein-coding gene located on chromosome 2q13. It encodes a protein that contains a RANBP2-like domain and a GRIP (glutamate receptor interacting protein) domain, suggesting potential roles in nuclear transport and receptor signaling. The gene is part of a family of RANBP2-like genes, though its specific functions remain under investigation. Expression data indicate low to moderate levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.8 | Low |
| Brain | 1.5 | Low |
| Lung | 1.2 | Low |
| Liver | 0.9 | Not detected |
| Heart | 0.7 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.0 | Low expression |
| HeLa | 0.8 | Low expression |
| K562 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants curated | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) |
Pathways
• No curated pathways
Protein Summary
The RGPD3 protein (UniProt Q9H6Z4) is 1,524 amino acids long and contains a RANBP2-like domain and a GRIP domain. It is predicted to localize to the nucleus and cytoplasm, potentially involved in nuclear transport and protein-protein interactions. Expression is low across most tissues, with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RGPD3 Knockout HEK293 Cell Line | EDJ-KQ12005 | Human | 653489 | Details Get a Quote |
| RGPD3 Knockout HeLa Cell Line | EDJ-KQ60648 | Human | 653489 | Details Get a Quote |
| RGPD3 Knockout A-549 Cell Line | EDJ-KQ69121 | Human | 653489 | Details Get a Quote |
| RGPD3 Knockout HCT 116 Cell Line | EDJ-KQ77473 | Human | 653489 | Details Get a Quote |
