RGPD2: RANBP2-Like and GRIP Domain-Containing Protein 2
A member of the RANBP2 family with roles in nuclear transport and cellular organization
Gene Information Card
| Symbol | RGPD2 |
|---|---|
| Full Name | RANBP2-like and GRIP domain-containing protein 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 2q13 |
| NCBI Gene ID | 729533 ncbi.nlm.nih.gov/gene/729533 |
| Ensembl ID | ENSG00000162944 |
| UniProt ID | Q9H6Z4 |
| OMIM ID | 612408 |
| HGNC ID | 29026 |
| Aliases | RANBP2L2, RANBP2-like 2, GRIP domain-containing 2 |
Description
RGPD2 encodes a protein containing a RANBP2-like domain and a GRIP (glutamate receptor-interacting protein) domain. It is part of a gene family on chromosome 2q13 and is involved in nuclear transport and protein-protein interactions. The protein localizes to the nuclear pore complex and may play a role in nucleocytoplasmic transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Liver | 1.5 | Not detected |
| Heart | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Moderate expression |
| HeLa | 3.0 | Low expression |
| K562 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nuclear pore (GO:0005643) |
| • nuclear export (GO:0051168) | • Ran GTPase binding (GO:0008536) |
Pathways
• Nuclear pore complex assembly
• Ran-mediated nuclear transport
Protein Summary
The RGPD2 protein (UniProt Q9H6Z4) is a 1,024-amino acid polypeptide with a RANBP2-like domain and a GRIP domain. It is predicted to localize to the nuclear pore complex and may function in Ran-dependent nucleocytoplasmic transport. Expression is low in most tissues, with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RGPD2 Knockout HEK293 Cell Line | EDJ-KQ15052 | Human | 729857 | Details Get a Quote |
| RGPD2 Knockout HeLa Cell Line | EDJ-KQ60764 | Human | 729857 | Details Get a Quote |
| RGPD2 Knockout A-549 Cell Line | EDJ-KQ69233 | Human | 729857 | Details Get a Quote |
| RGPD2 Knockout HCT 116 Cell Line | EDJ-KQ77590 | Human | 729857 | Details Get a Quote |
