REXO5
RNA exonuclease 5
Gene Information Card
| Symbol | REXO5 |
|---|---|
| Full Name | RNA exonuclease 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 727956 ncbi.nlm.nih.gov/gene/727956 |
| Ensembl ID | ENSG00000204310 |
| UniProt ID | Q8N6T3 |
| OMIM ID | 617849 |
| HGNC ID | HGNC:33704 |
| Aliases | MGC16384, FLJ22170, C16orf13 |
Description
REXO5 (RNA exonuclease 5) is a protein-coding gene that encodes a 3'-5' exoribonuclease involved in RNA processing and degradation. The protein localizes to the nucleus and participates in the exosome complex-mediated RNA surveillance pathway. REXO5 is expressed in multiple tissues and has been implicated in cellular RNA homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 8.7 | Low |
| Lung | 6.2 | Low |
| Brain | 4.1 | Low |
| Liver | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Moderate expression |
| HeLa | 7.2 | Low expression |
| K562 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • 3'-5' exoribonuclease activity | • RNA binding |
| • nucleus | • cytoplasm |
| • RNA catabolic process |
Pathways
• RNA degradation
• Exosome complex pathway
Protein Summary
REXO5 encodes a 3'-5' exoribonuclease that is part of the RNA exosome complex. The protein contains an RNB domain characteristic of exoribonucleases and is involved in the processing and degradation of various RNA species, including ribosomal RNA and messenger RNA. It is ubiquitously expressed with higher levels in testis and thyroid.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| REXO5 Knockout HEK293 Cell Line | EDJ-KQ8957 | Human | 81691 | Details Get a Quote |
| REXO5 Knockout A-549 Cell Line | EDJ-KQ36568 | Human | 81691 | Details Get a Quote |
| REXO5 Knockout HCT 116 Cell Line | EDJ-KQ36569 | Human | 81691 | Details Get a Quote |
| REXO5 Knockout HeLa Cell Line | EDJ-KQ36570 | Human | 81691 | Details Get a Quote |
