REM1 (RRAD and GEM Like GTPase 1)
A member of the RGK family of small GTPases involved in calcium channel regulation and cell signaling.
Gene Information Card
| Symbol | REM1 |
|---|---|
| Full Name | RRAD and GEM Like GTPase 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 28954 ncbi.nlm.nih.gov/gene/28954 |
| Ensembl ID | ENSG00000101282 |
| UniProt ID | O75628 |
| OMIM ID | 607672 |
| HGNC ID | 9950 |
| Aliases | GES, MGC131895, MGC149531 |
Description
REM1 (RRAD and GEM Like GTPase 1) is a member of the RGK (Rad, Gem, Rem) subfamily of small GTPases. It functions as a negative regulator of voltage-gated calcium channels (CaV) by binding to the β-subunit, thereby modulating calcium influx and downstream signaling. REM1 is involved in cell proliferation, differentiation, and cytoskeletal dynamics. Its expression is regulated in a tissue-specific manner and has been implicated in cancer and cardiovascular diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | REM1 overexpression may promote tumor growth via altered calcium signaling and cell cycle progression. | COSMIC; PMID: 23454898 |
| Cardiovascular disease | REM1 modulates L-type calcium channels in cardiac and vascular smooth muscle, affecting contractility and blood pressure regulation. | PMID: 15611091; PMID: 18332113 |
| Diabetes | REM1 expression in pancreatic β-cells influences insulin secretion through calcium channel regulation. | PMID: 15611091 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 8.3 | Low |
| Brain | 6.1 | Low |
| Lung | 4.7 | Low |
| Kidney | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Moderate expression |
| HeLa | 8.9 | Low expression |
| MCF7 | 22.4 | High expression |
| A549 | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.482G>A (p.Arg161Gln) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen-2 |
| c.601_603del (p.Lys201del) | In-frame deletion | <0.01% | Unknown; may affect protein stability |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in REM1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in REM1.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in REM1.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activity | • calcium channel regulator activity |
| • protein binding | • intracellular signal transduction |
| • regulation of calcium ion transport | • negative regulation of voltage-gated calcium channel activity |
Pathways
• Regulation of cardiac conduction
• Calcium signaling pathway
• RGK GTPase regulation of CaV channels
Protein Summary
REM1 encodes a 297-amino acid protein belonging to the RGK family of small GTPases. It contains a GTP-binding domain and a C-terminal calmodulin-binding domain. REM1 localizes to the plasma membrane and cytosol, where it interacts with the β-subunit of voltage-gated calcium channels (CaVβ) to inhibit channel activity. This regulation impacts calcium-dependent processes such as muscle contraction, hormone secretion, and gene expression. REM1 also binds calmodulin, linking calcium signaling to cellular responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GREM1 Knockout HEK293 Cell Line | EDJ-KQ381 | Human | 26585 | Details Get a Quote |
| FREM1 Knockout HEK293 Cell Line | EDJ-KQ2975 | Human | 158326 | Details Get a Quote |
| REM1 Knockout HEK293 Cell Line | EDJ-KQ8939 | Human | 28954 | Details Get a Quote |
| GAREM1 Knockout HEK293 Cell Line | EDJ-KQ13561 | Human | 64762 | Details Get a Quote |
| TREM1 Knockout HEK293 Cell Line | EDJ-KQ15910 | Human | 54210 | Details Get a Quote |
| GAREM1 Knockout A-549 Cell Line | EDJ-KQ43193 | Human | 64762 | Details Get a Quote |
| GAREM1 Knockout HCT 116 Cell Line | EDJ-KQ43194 | Human | 64762 | Details Get a Quote |
| GAREM1 Knockout HeLa Cell Line | EDJ-KQ43195 | Human | 64762 | Details Get a Quote |
| GREM1 Knockout A-549 Cell Line | EDJ-KQ18586 | Human | 26585 | Details Get a Quote |
| GREM1 Knockout HeLa Cell Line | EDJ-KQ18587 | Human | 26585 | Details Get a Quote |
| TREM1 Knockout HTR-8/SVneo Cell Line | EDJ-KZ60 | Human | 54210 | Details Get a Quote |
| REM1 Knockout HeLa Cell Line | EDJ-KQ56076 | Human | 28954 | Details Get a Quote |
| TREM1 Knockout HeLa Cell Line | EDJ-KQ56403 | Human | 54210 | Details Get a Quote |
| FREM1 Knockout HeLa Cell Line | EDJ-KQ58783 | Human | 158326 | Details Get a Quote |
| REM1 Knockout A-549 Cell Line | EDJ-KQ64560 | Human | 28954 | Details Get a Quote |
Displaying Records 1 To 15 Of 21 Records
