REG3G (Regenerating Family Member 3 Gamma)
A C-type lectin involved in antimicrobial defense, tissue regeneration, and pancreatic disease.
Gene Information Card
| Symbol | REG3G |
|---|---|
| Full Name | Regenerating Family Member 3 Gamma |
| Gene Type | Protein coding |
| Chromosomal Location | 2p12 |
| NCBI Gene ID | 130120 ncbi.nlm.nih.gov/gene/130120 |
| Ensembl ID | ENSG00000143942 |
| UniProt ID | Q6UW15 |
| OMIM ID | 609533 |
| HGNC ID | 17900 |
| Aliases | REG-III, REG3, PAP1B, HIP/PAP-1B |
Description
REG3G (Regenerating Family Member 3 Gamma) encodes a secreted C-type lectin protein involved in antimicrobial defense, tissue regeneration, and inflammatory responses. It is highly expressed in the pancreas and small intestine, where it acts as a bactericidal agent against Gram-positive bacteria. REG3G is also implicated in pancreatic regeneration and is upregulated in pancreatitis and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatitis | Upregulation of REG3G in acinar cells during acute pancreatitis; may promote regeneration or modulate inflammation. | PMID: 21576517 |
| Pancreatic Ductal Adenocarcinoma | Overexpression in tumor tissues; potential role in tumor progression and immune evasion. | PMID: 25977331 |
| Inflammatory Bowel Disease | Increased expression in intestinal epithelium; antimicrobial activity against gut pathogens. | PMID: 17008539 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 112.5 | High |
| Small Intestine | 45.2 | Medium |
| Stomach | 12.8 | Low |
| Colon | 8.3 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic cancer) | 78.4 | High expression |
| Caco-2 (colorectal) | 22.1 | Moderate expression |
| HepG2 (hepatocellular) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94C>T (p.Arg32Cys) | Missense | <0.1% | Unknown; rare variant in population databases |
| c.218G>A (p.Arg73His) | Missense | <0.1% | Unknown; no functional studies reported |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • carbohydrate binding (GO:0030246) |
| • defense response to bacterium (GO:0042742) | • extracellular space (GO:0005615) |
| • immune response (GO:0006955) |
Pathways
• KEGG: hsa04610 (Complement and coagulation cascades) - indirect
• Reactome: R-HSA-6798695 (Neutrophil degranulation)
Protein Summary
REG3G is a 175-amino-acid secreted C-type lectin (UniProt Q6UW15) that forms homodimers and binds bacterial peptidoglycan. It exhibits bactericidal activity against Gram-positive bacteria by disrupting cell wall synthesis. The protein is upregulated during pancreatic inflammation and is considered a biomarker for acute pancreatitis. Its expression is regulated by the NF-κB pathway and is induced by bacterial products.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| REG3G Knockout HEK293 Cell Line | EDJ-KQ9233 | Human | 130120 | Details Get a Quote |
| REG3G Knockout HeLa Cell Line | EDJ-KQ58274 | Human | 130120 | Details Get a Quote |
| REG3G Knockout A-549 Cell Line | EDJ-KQ66762 | Human | 130120 | Details Get a Quote |
| REG3G Knockout HCT 116 Cell Line | EDJ-KQ75169 | Human | 130120 | Details Get a Quote |
