REG3A: Regenerating Family Member 3 Alpha
A C-type lectin with roles in antimicrobial defense, tissue regeneration, and pancreatic disease
Gene Information Card
| Symbol | REG3A |
|---|---|
| Full Name | Regenerating Family Member 3 Alpha |
| Gene Type | Protein coding |
| Chromosomal Location | 2p12 |
| NCBI Gene ID | 5068 ncbi.nlm.nih.gov/gene/5068 |
| Ensembl ID | ENSG00000172023 |
| UniProt ID | Q06141 |
| OMIM ID | 167805 |
| HGNC ID | 9958 |
| Aliases | HIP, PAP, PAP1, REG3, REG-III |
Description
REG3A encodes a C-type lectin protein that belongs to the regenerating gene family. It is secreted by pancreatic acinar cells and intestinal Paneth cells, functioning as an antimicrobial peptide and a growth factor involved in tissue regeneration, inflammation, and cell proliferation. REG3A is upregulated in pancreatitis and certain cancers, including pancreatic ductal adenocarcinoma.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatitis | Upregulation of REG3A in acinar cells during acute pancreatitis; acts as a stress-induced survival factor | PMID: 10861084 |
| Pancreatic Ductal Adenocarcinoma | Overexpression promotes tumor cell proliferation and migration via STAT3 and MAPK pathways | PMID: 25695633 |
| Inflammatory Bowel Disease | REG3A expressed in intestinal epithelium; antimicrobial activity against gut microbiota may modulate inflammation | PMID: 17008549 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 125.4 | High |
| Small Intestine | 45.2 | Medium |
| Stomach | 12.8 | Low |
| Colon | 8.5 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 78.3 | Pancreatic cancer cell line |
| Caco-2 | 22.1 | Colorectal adenocarcinoma cell line |
| HeLa | 0.5 | Cervical cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Gly32Arg) | Missense | <0.01% | Unknown functional impact |
| c.287C>T (p.Thr96Met) | Missense | <0.01% | Reported in COSMIC; no known pathogenicity |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
Overexpression in pancreatic cancer suggests potential gain-of-function role, but no specific activating mutations identified.
Dominant Negative (DN)
Not described for REG3A.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • carbohydrate binding (GO:0030246) |
| • defense response to bacterium (GO:0042742) | • cell population proliferation (GO:0008283) |
| • defense response (GO:0006952) |
Pathways
• REACT: R-HSA-6798695 – Neutrophil degranulation
• REACT: R-HSA-168256 – Immune System
• REACT: R-HSA-2122948 – Antimicrobial peptides
Protein Summary
REG3A is a 175-amino acid secreted C-type lectin with a single carbohydrate recognition domain. It is synthesized as a preproprotein and processed to a mature form. The protein exhibits bactericidal activity against Gram-positive bacteria and promotes cell growth and survival in pancreatic and intestinal epithelial cells. Its expression is induced by inflammatory stimuli and tissue injury.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| REG3A Knockout HEK293 Cell Line | EDJ-KQ5401 | Human | 5068 | Details Get a Quote |
| REG3A Knockout HeLa Cell Line | EDJ-KQ54078 | Human | 5068 | Details Get a Quote |
| REG3A Knockout A-549 Cell Line | EDJ-KQ62566 | Human | 5068 | Details Get a Quote |
| REG3A Knockout HCT 116 Cell Line | EDJ-KQ71036 | Human | 5068 | Details Get a Quote |
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