RBPMS Gene - RNA-Binding Protein with Multiple Splicing | Function, Expression & Disease

RBPMS (RNA Binding Protein, mRNA Processing Factor) encodes a member of the RNA recognition motif (RRM) family of RNA-binding proteins. It is involved in post-transcriptional regulation, including alternative splicing, mRNA stability, and translation. RBPMS is highly expressed in smooth muscle tissues and plays a critical role in maintaining the contractile phenotype of smooth muscle cells. It also functions as a cofactor for the transcription factor SRF (serum response factor) and is implicated in cancer, particularly in colorectal and breast cancer, where it may act as a tumor suppressor or oncogene depending on context.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• SRF-dependent gene expression (Reactome: R-HSA-525793)

• mRNA Splicing - Major Pathway (Reactome: R-HSA-72163)

• Processing of Capped Intron-Containing Pre-mRNA (Reactome: R-HSA-72203)

The RBPMS protein (UniProt Q93062) contains a single N-terminal RNA recognition motif (RRM) that mediates binding to RNA targets, particularly in the 3' UTR of mRNAs. It shuttles between the nucleus and cytoplasm and interacts with SRF to regulate smooth muscle-specific gene expression. RBPMS also modulates alternative splicing of transcripts involved in cell proliferation and migration. Its expression is frequently lost in aggressive cancers, suggesting a tumor-suppressive role.