RBM42 Gene - RNA Binding Motif Protein 42 | Function, Mutations & Disease

RBM42 (RNA Binding Motif Protein 42) is a protein-coding gene located on chromosome 19q13.12. It encodes a member of the RNA-binding protein family, characterized by an RNA recognition motif (RRM). RBM42 is involved in RNA processing, transcriptional regulation, and may play a role in cellular stress responses. The protein interacts with transcription factors and splicing factors, influencing gene expression. RBM42 has been implicated in various cancers, including breast and colorectal cancer, where its expression is dysregulated.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• RNA splicing (Reactome: R-HSA-72163)

• Gene expression (Reactome: R-HSA-74160)

• Processing of Capped Intron-Containing Pre-mRNA (Reactome: R-HSA-72203)

RBM42 encodes a 364-amino acid protein with a single N-terminal RNA recognition motif (RRM). The protein localizes to the nucleus and cytoplasm, and is involved in RNA binding and processing. It interacts with splicing factors and transcription regulators, modulating alternative splicing and gene expression. RBM42 is expressed in multiple tissues, with highest levels in testis and bone marrow. Dysregulation of RBM42 is associated with cancer progression, particularly in breast and colorectal cancers.