RASSF10
Ras Association Domain Family Member 10
Gene Information Card
| Symbol | RASSF10 |
|---|---|
| Full Name | Ras association domain family member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.2 |
| NCBI Gene ID | 644943 ncbi.nlm.nih.gov/gene/644943 |
| Ensembl ID | ENSG00000188846 |
| UniProt ID | A6NKZ8 |
| OMIM ID | 614666 |
| HGNC ID | 29956 |
| Aliases | C11orf77, RP11-81H14.2 |
Description
RASSF10 (Ras association domain family member 10) is a protein-coding gene located on chromosome 11p15.2. It belongs to the Ras association domain family and is thought to function as a tumor suppressor. The gene is frequently silenced by promoter hypermethylation in various cancers, including gastric, colorectal, and breast cancer. RASSF10 encodes a protein containing a Ras association (RA) domain, which may mediate interactions with Ras-like GTPases, though its exact biological role remains under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Promoter hypermethylation leading to transcriptional silencing | NCBI Gene, PubMed |
| Colorectal cancer | Epigenetic inactivation via CpG island methylation | NCBI Gene, PubMed |
| Breast cancer | Reduced expression due to promoter methylation | NCBI Gene, PubMed |
| Hepatocellular carcinoma | Loss of expression associated with methylation | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 3.2 | Low |
| Testis | 2.8 | Low |
| Thyroid | 2.1 | Low |
| Adrenal gland | 1.9 | Low |
| Prostate | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 1.0 | Low expression |
| HeLa | 0.8 | Low expression |
| MCF7 | 0.5 | Very low expression |
| HCT116 | 0.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown significance |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Promoter methylation and nonsense mutations are associated with loss of RASSF10 expression.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Ras GTPase binding | • protein binding |
| • cytoplasm | • nucleus |
Pathways
• Ras signaling pathway
• apoptosis
Protein Summary
The RASSF10 protein contains a Ras association (RA) domain and is localized to the cytoplasm and nucleus. It is implicated in cell growth regulation and apoptosis, likely through interaction with Ras family proteins. Loss of RASSF10 expression via epigenetic silencing contributes to tumorigenesis in multiple cancer types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RASSF10 Knockout HEK293 Cell Line | EDJ-KQ14999 | Human | 644943 | Details Get a Quote |
| RASSF10 Knockout A-549 Cell Line | EDJ-KQ45518 | Human | 644943 | Details Get a Quote |
| RASSF10 Knockout HeLa Cell Line | EDJ-KQ60577 | Human | 644943 | Details Get a Quote |
| RASSF10 Knockout HCT 116 Cell Line | EDJ-KQ77401 | Human | 644943 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
