RANBP9
RAN Binding Protein 9: A scaffold protein involved in signal transduction, cell cycle regulation, and cancer progression.
Gene Information Card
| Symbol | RANBP9 |
|---|---|
| Full Name | RAN Binding Protein 9 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p23 |
| NCBI Gene ID | 10048 ncbi.nlm.nih.gov/gene/10048 |
| Ensembl ID | ENSG00000112659 |
| UniProt ID | Q96S59 |
| OMIM ID | 603854 |
| HGNC ID | 9850 |
| Aliases | RANBPM, RanBP7, RanBP9 |
Description
RANBP9 encodes a scaffold protein that interacts with RAN, a small GTPase involved in nucleocytoplasmic transport. The protein also binds to various signaling molecules, including receptors for TGF-beta, BMP, and androgen, modulating their activity. It plays roles in cell cycle progression, apoptosis, and cytoskeletal organization. RANBP9 is implicated in several cancers, where it can act as either a tumor suppressor or oncogene depending on context.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | RANBP9 overexpression enhances cell proliferation and migration; interacts with androgen receptor to promote growth. | PMID: 21947297; COSMIC |
| Prostate Cancer | RANBP9 modulates androgen receptor signaling; altered expression correlates with disease progression. | PMID: 21947297; COSMIC |
| Colorectal Cancer | RANBP9 expression is upregulated; promotes invasion and metastasis via EMT pathways. | PMID: 25620004; COSMIC |
| Lung Cancer | RANBP9 overexpression associated with poor prognosis; promotes cell cycle progression. | PMID: 25620004; COSMIC |
| Hepatocellular Carcinoma | RANBP9 expression is elevated; contributes to cell proliferation and migration. | PMID: 25620004; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 10.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Breast | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Embryonic kidney; high expression |
| HeLa | 9.5 | Cervical cancer; moderate expression |
| MCF7 | 7.8 | Breast cancer; moderate expression |
| A549 | 6.2 | Lung cancer; low expression |
| HepG2 | 5.0 | Liver cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Unknown; rare variant in COSMIC |
| c.567G>A (p.Gly189Arg) | Missense | <0.1% | Unknown; rare variant in COSMIC |
| c.890_891insA (p.Thr297fs) | Frameshift | <0.1% | Predicted loss of function; rare in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr297fs) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • signal transduction (GO:0007165) |
| • cell cycle (GO:0007049) | • apoptotic process (GO:0006915) |
| • cytoskeleton (GO:0005856) |
Pathways
• TGF-beta signaling pathway (Reactome: R-HSA-170834)
• BMP signaling pathway (Reactome: R-HSA-201451)
• Androgen receptor signaling pathway (Reactome: R-HSA-5625740)
• Cell Cycle
• Mitotic (Reactome: R-HSA-69278)
Protein Summary
RANBP9 is a 729-amino acid scaffold protein containing a SPRY domain and a LisH motif. It localizes to the cytoplasm and nucleus, interacting with RAN, various receptors (e.g., TGFBR1, BMPR1A, AR), and signaling intermediates. It modulates receptor trafficking, signal transduction, and cell cycle progression. The protein is widely expressed, with highest levels in testis and brain. Dysregulation of RANBP9 is linked to multiple cancers, where it can promote or suppress tumorigenesis depending on cellular context.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RANBP9 Knockout HEK293 Cell Line | EDJ-KQ6877 | Human | 10048 | Details Get a Quote |
| RANBP9 Knockout A-549 Cell Line | EDJ-KQ31467 | Human | 10048 | Details Get a Quote |
| RANBP9 Knockout HCT 116 Cell Line | EDJ-KQ31468 | Human | 10048 | Details Get a Quote |
| RANBP9 Knockout HeLa Cell Line | EDJ-KQ31469 | Human | 10048 | Details Get a Quote |
