RANBP10
RAN Binding Protein 10
Gene Information Card
| Symbol | RANBP10 |
|---|---|
| Full Name | RAN Binding Protein 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 16q22.1 |
| NCBI Gene ID | 57613 ncbi.nlm.nih.gov/gene/57613 |
| Ensembl ID | ENSG00000103174 |
| UniProt ID | Q6VN20 |
| OMIM ID | 609750 |
| HGNC ID | 29285 |
| Aliases | RANBP10, RAN-binding protein 10 |
Description
RANBP10 encodes a protein that belongs to the RAN-binding protein family. It interacts with the small GTPase RAN, which is involved in nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation. RANBP10 may modulate RAN activity and influence cell cycle progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | Not available |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 7.1 | Low |
| Spleen | 6.8 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 10.1 | Leukemia cell line |
| HEK 293 | 9.5 | Embryonic kidney |
| HeLa | 8.3 | Cervical carcinoma |
| HepG2 | 7.6 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not documented
Gain of Function (GOF)
Not documented
Dominant Negative (DN)
Not documented
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • nuclear transport |
| • GTPase binding | • cytoplasm |
| • nucleus |
Pathways
• RAN GTPase cycle
• Nuclear import/export
Protein Summary
RANBP10 is a 648-amino acid protein that contains a RAN-binding domain. It localizes to the cytoplasm and nucleus, and is thought to regulate RAN-mediated nucleocytoplasmic transport. Its expression is highest in testis and hematopoietic tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RANBP10 Knockout HEK293 Cell Line | EDJ-KQ14990 | Human | 57610 | Details Get a Quote |
| RANBP10 Knockout A-549 Cell Line | EDJ-KQ45496 | Human | 57610 | Details Get a Quote |
| RANBP10 Knockout HCT 116 Cell Line | EDJ-KQ45497 | Human | 57610 | Details Get a Quote |
| RANBP10 Knockout HeLa Cell Line | EDJ-KQ45498 | Human | 57610 | Details Get a Quote |
