RAMP2: Receptor Activity Modifying Protein 2
Key regulator of adrenomedullin signaling and vascular homeostasis
Gene Information Card
| Symbol | RAMP2 |
|---|---|
| Full Name | Receptor Activity Modifying Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 10266 ncbi.nlm.nih.gov/gene/10266 |
| Ensembl ID | ENSG00000131477 |
| UniProt ID | O60895 |
| OMIM ID | 605154 |
| HGNC ID | 9844 |
| Aliases | RAMP2a, RAMP2b |
Description
RAMP2 (Receptor Activity Modifying Protein 2) encodes a member of the RAMP family of single-pass transmembrane proteins. RAMP2 forms a functional receptor complex with calcitonin receptor-like receptor (CALCRL) to create the adrenomedullin (AM) receptor. This complex is essential for vascular development, angiogenesis, and regulation of vascular tone. RAMP2 is also involved in lymphangiogenesis and cardiovascular homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lymphatic malformation | RAMP2 loss-of-function impairs adrenomedullin signaling, disrupting lymphatic endothelial cell development | PMID: 31133753 |
| Cardiovascular disease | RAMP2 deficiency leads to vascular fragility, hypotension, and impaired angiogenesis | PMID: 23395172 |
| Preeclampsia | Altered RAMP2 expression affects placental adrenomedullin signaling, contributing to hypertension | PMID: 21788487 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Heart | 9.8 | Medium |
| Placenta | 15.2 | High |
| Kidney | 7.1 | Low |
| Liver | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (umbilical vein endothelial) | 18.5 | High expression |
| A549 (lung carcinoma) | 6.2 | Moderate expression |
| HEK293 (embryonic kidney) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | missense | <0.01% | Loss of start codon, likely loss of function |
| c.218G>A (p.Arg73His) | missense | <0.01% | Impaired receptor trafficking |
| c.340C>T (p.Arg114Trp) | missense | <0.01% | Reduced adrenomedullin binding |
Mutation functional classification
Loss of Function (LOF)
RAMP2 loss-of-function mutations impair adrenomedullin receptor formation, leading to lymphatic and vascular defects.
Gain of Function (GOF)
No gain-of-function mutations reported in RAMP2.
Dominant Negative (DN)
No dominant-negative mutations reported in RAMP2.
View complete mutation data：
Gene Ontology (GO)
| • transmembrane signaling receptor activity (GO:0004888) | • protein binding (GO:0005515) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • receptor internalization (GO:0031623) | • steroid hormone mediated signaling pathway (GO:0043401) |
Pathways
• Adrenomedullin signaling pathway (Reactome: R-HSA-420092)
• GPCR ligand binding (Reactome: R-HSA-500792)
• Vascular smooth muscle contraction (KEGG: hsa04270)
Protein Summary
RAMP2 is a 175-amino acid single-pass transmembrane protein with an N-terminal extracellular domain and a short cytoplasmic tail. It functions as a chaperone and co-receptor for CALCRL, enabling adrenomedullin binding and signaling. RAMP2 is critical for endothelial cell survival, angiogenesis, and vascular integrity. Its expression is enriched in lung, heart, and placenta.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RAMP2 Knockout HEK293 Cell Line | EDJ-KQ6982 | Human | 10266 | Details Get a Quote |
| RAMP2 Knockout A-549 Cell Line | EDJ-KQ31685 | Human | 10266 | Details Get a Quote |
| RAMP2 Knockout HeLa Cell Line | EDJ-KQ55362 | Human | 10266 | Details Get a Quote |
| RAMP2 Knockout HCT 116 Cell Line | EDJ-KQ72303 | Human | 10266 | Details Get a Quote |
