RAI14: Retinoic Acid Induced 14
A cytoskeletal scaffold protein involved in cell migration and cancer progression
Gene Information Card
| Symbol | RAI14 |
|---|---|
| Full Name | Retinoic Acid Induced 14 |
| Gene Type | Protein coding |
| Chromosomal Location | 5p13.2 |
| NCBI Gene ID | 26064 ncbi.nlm.nih.gov/gene/26064 |
| Ensembl ID | ENSG00000113522 |
| UniProt ID | Q9P0K7 |
| OMIM ID | 606991 |
| HGNC ID | HNC:9839 |
| Aliases | NORPEG, KIAA1334 |
Description
RAI14 (retinoic acid induced 14) encodes a protein that localizes to the cytoplasm and cytoskeleton, involved in actin dynamics, cell migration, and adhesion. It is induced by retinoic acid and plays roles in spermatogenesis, neuronal development, and cancer cell invasion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression promotes cell migration and invasion via cytoskeletal remodeling | COSMIC, literature |
| Male infertility | Disruption of RAI14 in testis affects spermatid maturation | OMIM, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Brain | 8.3 | Medium |
| Lung | 6.1 | Medium |
| Breast | 4.7 | Low |
| Colon | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | High expression |
| A549 | 10.8 | Medium expression |
| MCF7 | 7.4 | Medium expression |
| HepG2 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.1% | Unknown functional impact |
| c.567_568insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants predicted to truncate the protein, reducing cytoskeletal scaffolding.
Gain of Function (GOF)
Not well characterized; overexpression in cancer suggests potential gain-of-function in migration.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • cytoskeleton | • actin binding |
| • cell migration | • cell adhesion |
| • protein binding |
Pathways
• Retinoic acid signaling
• Actin cytoskeleton regulation
• Cell adhesion
Protein Summary
The RAI14 protein is a 980-amino acid cytoskeletal scaffold that interacts with actin and other structural proteins. It is highly expressed in testis and brain, and its upregulation in various cancers correlates with increased metastatic potential.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RAI14 Knockout HEK293 Cell Line | EDJ-KQ8389 | Human | 26064 | Details Get a Quote |
| RAI14 Knockout A-549 Cell Line | EDJ-KQ34452 | Human | 26064 | Details Get a Quote |
| RAI14 Knockout HCT 116 Cell Line | EDJ-KQ34453 | Human | 26064 | Details Get a Quote |
| RAI14 Knockout HeLa Cell Line | EDJ-KQ34454 | Human | 26064 | Details Get a Quote |
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