RAET1E
Retinoic Acid Early Transcript 1E (NKG2D Ligand)
Gene Information Card
| Symbol | RAET1E |
|---|---|
| Full Name | Retinoic Acid Early Transcript 1E |
| Gene Type | Protein coding |
| Chromosomal Location | 6q25.1 |
| NCBI Gene ID | 135250 ncbi.nlm.nih.gov/gene/135250 |
| Ensembl ID | ENSG00000164520 |
| UniProt ID | Q8TD07 |
| OMIM ID | 609863 |
| HGNC ID | 16793 |
| Aliases | ULBP4, RAET1E2, N2DL-4 |
Description
RAET1E (Retinoic Acid Early Transcript 1E), also known as ULBP4, encodes a cell surface glycoprotein that serves as a ligand for the NKG2D receptor. This interaction activates natural killer (NK) cells and other immune effectors, playing a critical role in immune surveillance against tumors and viral infections. The gene is located on chromosome 6q25.1 within the ULBP/RAET1 gene cluster.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | RAET1E expression on tumor cells activates NKG2D-mediated cytotoxicity; shedding of soluble RAET1E may impair immune recognition. | COSMIC, ClinVar |
| Viral infections | Viral evasion mechanisms downregulate RAET1E to avoid NK cell activation. | NCBI, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
| Jurkat | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional impact |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein and loss of NKG2D binding.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • NKG2D ligand activity | • cell surface |
| • immune response | • signal transduction |
Pathways
• NKG2D signaling in natural killer cells
• Immune surveillance
Protein Summary
RAET1E (ULBP4) is a 261-amino acid type I transmembrane protein with an extracellular alpha-1/alpha-2 domain that binds the NKG2D receptor. It is expressed on the cell surface of certain tumor cells and infected cells, triggering NK cell activation. Soluble forms shed by tumors may contribute to immune evasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RAET1E Knockout HEK293 Cell Line | EDJ-KQ9359 | Human | 135250 | Details Get a Quote |
| RAET1E Knockout A-549 Cell Line | EDJ-KQ36005 | Human | 135250 | Details Get a Quote |
| RAET1E Knockout HCT 116 Cell Line | EDJ-KQ36006 | Human | 135250 | Details Get a Quote |
| RAET1E Knockout HeLa Cell Line | EDJ-KQ36007 | Human | 135250 | Details Get a Quote |
