RAB31: A Key Regulator of Vesicle Trafficking and Oncogenic Signaling
Comprehensive genomic and functional analysis of RAB31, a member of the RAS oncogene family involved in membrane trafficking and cancer progression.
Gene Information Card
| Symbol | RAB31 |
|---|---|
| Full Name | RAB31, member RAS oncogene family |
| Gene Type | protein-coding |
| Chromosomal Location | 18p11.22 |
| NCBI Gene ID | 11031 ncbi.nlm.nih.gov/gene/11031 |
| Ensembl ID | ENSG00000101412 |
| UniProt ID | Q13636 |
| OMIM ID | 605694 |
| HGNC ID | 9770 |
| Aliases | Rab22B, RAB31L1 |
Description
RAB31 (RAB31, member RAS oncogene family) is a protein-coding gene that encodes a small GTPase belonging to the RAS superfamily. RAB31 regulates intracellular membrane trafficking, including endocytosis and exocytosis, and is implicated in cell proliferation, migration, and invasion. Overexpression of RAB31 has been observed in several cancers, including breast, lung, and gastric cancers, where it promotes tumor progression and poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | RAB31 overexpression enhances EGFR recycling and PI3K/AKT signaling, promoting cell proliferation and invasion. | PMID: 25609832 |
| Gastric cancer | RAB31 upregulation correlates with lymph node metastasis and poor survival; promotes EMT via TGF-β pathway. | PMID: 29367643 |
| Lung adenocarcinoma | RAB31 is a direct target of miR-215 and its silencing reduces tumor growth and metastasis. | PMID: 31073084 |
| Glioblastoma | RAB31 is overexpressed and associated with poor prognosis; regulates EGFR trafficking and signaling. | PMID: 27562872 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Lung | 15.2 | Medium |
| Stomach | 20.1 | High |
| Liver | 6.7 | Low |
| Kidney | 10.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.9 | High expression; associated with invasive phenotype |
| A549 (lung cancer) | 22.3 | High expression; promotes migration |
| HCT116 (colon cancer) | 14.5 | Moderate expression |
| U87MG (glioblastoma) | 25.1 | Very high expression; linked to poor prognosis |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.173A>G (p.Gln58Arg) | Missense | <0.1% | Alters GTP binding; potential gain-of-function |
| c.344C>T (p.Thr115Met) | Missense | <0.1% | Unknown functional impact |
| c.487G>A (p.Glu163Lys) | Missense | <0.1% | Located in hypervariable region; may affect membrane localization |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in RAB31.
Gain of Function (GOF)
p.Gln58Arg may enhance GTP binding and downstream signaling, potentially acting as an oncogenic driver.
Dominant Negative (DN)
No dominant-negative mutations described for RAB31.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Endocytosis (KEGG: hsa04144)
• Ras signaling pathway (KEGG: hsa04014)
• EGFR tyrosine kinase inhibitor resistance (KEGG: hsa01521)
• Vesicle-mediated transport (Reactome: R-HSA-5653656)
Protein Summary
RAB31 is a small GTPase of the Rab family that cycles between an active GTP-bound and inactive GDP-bound state. It localizes to endosomes and the perinuclear region, regulating endocytic trafficking and recycling of receptors such as EGFR. RAB31 promotes cell migration, invasion, and proliferation through activation of PI3K/AKT and MAPK pathways. Its overexpression in multiple cancers correlates with poor prognosis, making it a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RAB31 Knockout HEK293 Cell Line | EDJ-KQ2369 | Human | 11031 | Details Get a Quote |
| RAB31 Knockout A-549 Cell Line | EDJ-KQ22819 | Human | 11031 | Details Get a Quote |
| RAB31 Knockout HCT 116 Cell Line | EDJ-KQ22820 | Human | 11031 | Details Get a Quote |
| RAB31 Knockout HeLa Cell Line | EDJ-KQ22821 | Human | 11031 | Details Get a Quote |
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