RAB26: A Key Regulator of Vesicle Trafficking and Secretory Pathways
Comprehensive genomic and functional analysis of RAB26, a member of the RAS oncogene family involved in exocytosis and autophagy.
Gene Information Card
| Symbol | RAB26 |
|---|---|
| Full Name | RAB26, member RAS oncogene family |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 55637 ncbi.nlm.nih.gov/gene/55637 |
| Ensembl ID | ENSG00000167978 |
| UniProt ID | Q9ULW5 |
| OMIM ID | 612909 |
| HGNC ID | 30266 |
| Aliases | RAB26, member RAS oncogene family; FLJ20580 |
Description
RAB26 is a member of the RAS oncogene family of small GTPases. It functions as a key regulator of vesicle trafficking, particularly in exocytosis and autophagy. RAB26 is involved in the secretion of insulin from pancreatic beta cells and in the regulation of autophagic flux. It is also implicated in cancer progression and neurodegenerative diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetes mellitus (type 2) | RAB26 regulates insulin granule exocytosis in pancreatic beta cells; impaired function leads to reduced insulin secretion. | PMID: 23415227 |
| Breast cancer | RAB26 overexpression promotes tumor growth and metastasis via enhanced exocytosis of pro-invasive factors. | PMID: 28753428 |
| Lung adenocarcinoma | RAB26 mutations and altered expression correlate with poor prognosis and increased metastatic potential. | COSMIC analysis |
| Neurodegenerative disorders (Alzheimer's disease) | RAB26 modulates autophagic clearance of amyloid-beta; dysregulation contributes to protein aggregation. | PMID: 31073057 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Lung | 6.1 | Low |
| Breast | 4.7 | Low |
| Liver | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression; associated with invasive phenotype |
| A549 (lung adenocarcinoma) | 10.8 | Moderate expression; mutation hotspot |
| MIN6 (pancreatic beta cell) | 18.5 | High expression; critical for insulin secretion |
| SH-SY5Y (neuroblastoma) | 7.4 | Moderate expression; role in autophagy |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437G>A (p.Arg146Gln) | Missense | 0.02% (gnomAD) | Alters GTP-binding affinity; potential loss of function |
| c.584T>C (p.Leu195Pro) | Missense | 0.01% (gnomAD) | Disrupts membrane localization; reduced exocytosis |
| c.123_124insA (p.Glu42Argfs*5) | Frameshift | <0.01% (COSMIC) | Truncated protein; loss of function in cancer |
| c.742G>T (p.Glu248*) | Nonsense | <0.01% (COSMIC) | Premature stop; loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg146Gln) and truncating variants (p.Glu42Argfs*5, p.Glu248*) impair GTP binding or protein stability, reducing vesicle trafficking and autophagy.
Gain of Function (GOF)
Not well-documented; overexpression in breast cancer may act as a gain-of-function by enhancing exocytosis of oncogenic factors.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported; some missense variants may exert dominant-negative effects by sequestering effectors.
View complete mutation data：
Gene Ontology (GO)
Pathways
• RAB26 regulates insulin secretion (Reactome: R-HSA-422085)
• Autophagy - RAB26 modulates autophagosome-lysosome fusion (KEGG: hsa04140)
• Vesicle-mediated transport (Reactome: R-HSA-5653656)
Protein Summary
RAB26 is a small GTPase of the Rab family, localized to secretory vesicles and autophagic membranes. It cycles between an active GTP-bound state and an inactive GDP-bound state, controlling vesicle docking and fusion. In pancreatic beta cells, RAB26 facilitates insulin granule exocytosis. In cancer cells, it promotes secretion of matrix metalloproteinases and growth factors, enhancing invasion. RAB26 also plays a role in autophagy by recruiting tethering factors to autophagosomes. Its dysregulation is linked to diabetes, cancer, and neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RAB26 Knockout HEK293 Cell Line | EDJ-KQ8267 | Human | 25837 | Details Get a Quote |
| RAB26 Knockout A-549 Cell Line | EDJ-KQ34209 | Human | 25837 | Details Get a Quote |
| RAB26 Knockout HCT 116 Cell Line | EDJ-KQ34210 | Human | 25837 | Details Get a Quote |
| RAB26 Knockout HeLa Cell Line | EDJ-KQ32891 | Human | 25837 | Details Get a Quote |
