QRFP Gene (Pyroglutamylated RFamide Peptide)
Comprehensive gene card for QRFP, encoding a neuropeptide involved in appetite regulation and energy homeostasis.
Gene Information Card
| Symbol | QRFP |
|---|---|
| Full Name | Pyroglutamylated RFamide Peptide |
| Gene Type | Protein coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 347148 ncbi.nlm.nih.gov/gene/347148 |
| Ensembl ID | ENSG00000188710 |
| UniProt ID | Q6T4P5 |
| OMIM ID | 609607 |
| HGNC ID | 29522 |
| Aliases | P518, QRFP-43, QRFP-26, RF-amide-related peptide |
Description
QRFP (pyroglutamylated RFamide peptide) is a gene that encodes a neuropeptide precursor. The mature peptides (QRFP-43 and QRFP-26) are ligands for the G protein-coupled receptor GPR103 (QRFPR). QRFP is involved in the regulation of appetite, energy balance, and feeding behavior. It is primarily expressed in the central nervous system and peripheral tissues such as the pancreas and adrenal glands.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | QRFP signaling modulates appetite; dysregulation may contribute to hyperphagia and obesity. | Animal models and association studies (PMID: 16988026) |
| Type 2 Diabetes | QRFP influences insulin secretion and glucose homeostasis. | Expression studies in pancreatic islets (PMID: 17374880) |
| Metabolic Syndrome | Altered QRFP levels linked to energy imbalance and metabolic dysfunction. | Clinical association studies (PMID: 19401456) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.3 | Low |
| Pancreas | 1.8 | Low |
| Adrenal Gland | 1.5 | Low |
| Testis | 0.9 | Not detected |
| Liver | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 0.5 | Low expression |
| HeLa (cervical carcinoma) | 0.1 | Not detected |
| HepG2 (hepatocellular carcinoma) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | Unknown; rare variant in population databases |
Mutation functional classification
Loss of Function (LOF)
p.Met1Val likely abolishes translation initiation, leading to loss of QRFP peptide production.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • neuropeptide signaling pathway | • G protein-coupled receptor signaling pathway |
| • feeding behavior | • hormone activity |
| • extracellular region |
Pathways
• Neuropeptide signaling (QRFPR pathway)
• GPCR downstream signaling
Protein Summary
The QRFP protein is a precursor that is cleaved into two bioactive peptides: QRFP-43 (43 amino acids) and QRFP-26 (26 amino acids). These peptides bind to the GPR103 receptor (QRFPR) to regulate appetite and energy expenditure. The protein is secreted and acts as a neuroendocrine modulator.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| QRFPR Knockout HEK293 Cell Line | EDJ-KQ9986 | Human | 84109 | Details Get a Quote |
| QRFP Knockout HEK293 Cell Line | EDJ-KQ14970 | Human | 347148 | Details Get a Quote |
| QRFP Knockout HCT 116 Cell Line | EDJ-KQ45457 | Human | 347148 | Details Get a Quote |
| QRFP Knockout HeLa Cell Line | EDJ-KQ45458 | Human | 347148 | Details Get a Quote |
| QRFPR Knockout HeLa Cell Line | EDJ-KQ57537 | Human | 84109 | Details Get a Quote |
| QRFPR Knockout A-549 Cell Line | EDJ-KQ66035 | Human | 84109 | Details Get a Quote |
| QRFP Knockout A-549 Cell Line | EDJ-KQ68275 | Human | 347148 | Details Get a Quote |
| QRFPR Knockout HCT 116 Cell Line | EDJ-KQ74459 | Human | 84109 | Details Get a Quote |
