PYY (Peptide YY) Gene
Regulator of Appetite and Gastrointestinal Function
Gene Information Card
| Symbol | PYY |
|---|---|
| Full Name | Peptide YY |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 5697 ncbi.nlm.nih.gov/gene/5697 |
| Ensembl ID | ENSG00000131095 |
| UniProt ID | P10082 |
| OMIM ID | 600781 |
| HGNC ID | 9716 |
| Aliases | PYY-I, PYY1 |
Description
The PYY gene encodes Peptide YY, a 36-amino acid hormone secreted by L-cells in the distal gastrointestinal tract. It regulates appetite, gastric emptying, and pancreatic secretion. PYY acts via neuropeptide Y receptors (Y1, Y2, Y4, Y5) to reduce food intake and modulate energy homeostasis. Dysregulation is implicated in obesity, eating disorders, and gastrointestinal motility disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Reduced PYY levels lead to decreased satiety signaling and increased food intake | Clinical studies show lower fasting and postprandial PYY in obese individuals (PMID: 12499395) |
| Anorexia Nervosa | Elevated PYY contributes to excessive satiety and reduced caloric intake | Plasma PYY levels are significantly higher in anorexia patients (PMID: 16390859) |
| Irritable Bowel Syndrome (IBS) | Altered PYY secretion affects colonic motility and sensation | Reduced PYY expression in colonic mucosa of IBS patients (PMID: 19834466) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 48.2 | High |
| Small Intestine | 35.7 | High |
| Pancreas | 12.1 | Medium |
| Stomach | 8.5 | Medium |
| Adipose Tissue | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 (colon adenocarcinoma) | 15.4 | Enterocyte-like model |
| HT-29 (colorectal adenocarcinoma) | 8.2 | Low expression |
| HCT 116 (colorectal carcinoma) | 2.1 | Minimal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown functional effect; rare variant in population databases |
| c.205C>T (p.Arg69Trp) | Missense | <0.01% | Reported in ClinVar as uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PYY.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PYY.
Dominant Negative (DN)
Not applicable; no dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
| • hormone activity (GO:0005179) | • neuropeptide Y receptor binding (GO:0007218) |
| • adult feeding behavior (GO:0008343) | • regulation of appetite (GO:0032098) |
| • glucose homeostasis (GO:0042593) |
Pathways
• Neuropeptide Y signaling pathway (Reactome: R-HSA-388396)
• GPCR ligand binding (Reactome: R-HSA-375276)
Protein Summary
Peptide YY (PYY) is a 36-amino acid hormone processed to PYY(3-36), the major circulating form. It binds preferentially to Y2 receptors, inhibiting gastric motility and reducing appetite. PYY is secreted postprandially in proportion to caloric intake. Its anorexigenic effects make it a target for anti-obesity therapies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PYY Knockout HEK293 Cell Line | EDJ-KQ3372 | Human | 5697 | Details Get a Quote |
| PYY Knockout HeLa Cell Line | EDJ-KQ54248 | Human | 5697 | Details Get a Quote |
| PYY Knockout A-549 Cell Line | EDJ-KQ62739 | Human | 5697 | Details Get a Quote |
| PYY Knockout HCT 116 Cell Line | EDJ-KQ71210 | Human | 5697 | Details Get a Quote |
