PXDNL
Peroxidasin-like protein gene
Gene Information Card
| Symbol | PXDNL |
|---|---|
| Full Name | peroxidasin like |
| Gene Type | protein coding |
| Chromosomal Location | 8q11.23 |
| NCBI Gene ID | 137902 ncbi.nlm.nih.gov/gene/137902 |
| Ensembl ID | ENSG00000182318 |
| UniProt ID | A1KZ92 |
| OMIM ID | 617201 |
| HGNC ID | 33878 |
| Aliases | MGC45871, FLJ32709 |
Description
PXDNL (peroxidasin like) is a protein-coding gene located on chromosome 8q11.23. It encodes a peroxidase-like protein that may be involved in extracellular matrix formation and reactive oxygen species metabolism. The gene is expressed in various tissues, with highest levels in the heart and skeletal muscle.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 8.2 | Medium |
| Skeletal Muscle | 6.5 | Medium |
| Liver | 2.1 | Low |
| Kidney | 1.8 | Low |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 3.4 | Low expression |
| HeLa | 1.2 | Very low |
| K562 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • heme binding | • peroxidase activity |
| • extracellular region |
Pathways
• No curated pathways
Protein Summary
The PXDNL protein is a predicted peroxidase that may function in extracellular matrix organization. It contains a peroxidase domain and is structurally similar to peroxidasin (PXDN). Its precise biological role remains to be fully characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PXDNL Knockout HEK293 Cell Line | EDJ-KQ9399 | Human | 137902 | Details Get a Quote |
| PXDNL Knockout HeLa Cell Line | EDJ-KQ58380 | Human | 137902 | Details Get a Quote |
| PXDNL Knockout A-549 Cell Line | EDJ-KQ66868 | Human | 137902 | Details Get a Quote |
| PXDNL Knockout HCT 116 Cell Line | EDJ-KQ75270 | Human | 137902 | Details Get a Quote |
