PTPRO: Protein Tyrosine Phosphatase Receptor Type O
A receptor-type protein tyrosine phosphatase implicated in cancer and immune regulation
Gene Information Card
| Symbol | PTPRO |
|---|---|
| Full Name | Protein Tyrosine Phosphatase Receptor Type O |
| Gene Type | Protein coding |
| Chromosomal Location | 12p12.3 |
| NCBI Gene ID | 5800 ncbi.nlm.nih.gov/gene/5800 |
| Ensembl ID | ENSG00000111224 |
| UniProt ID | Q16827 |
| OMIM ID | 600579 |
| HGNC ID | 9665 |
| Aliases | PTP-U2, GLEPP1, PTPRO, PTPRO1, PTPRO2 |
Description
PTPRO encodes a member of the R3 subfamily of receptor-type protein tyrosine phosphatases. The protein is a transmembrane phosphatase involved in the regulation of cell growth, differentiation, and oncogenic signaling. It is predominantly expressed in epithelial cells and B lymphocytes, where it modulates B-cell receptor signaling and acts as a tumor suppressor in several cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Loss of PTPRO expression leads to increased STAT3 and EGFR signaling, promoting tumor growth | PMID: 21502544 |
| Lung cancer | Promoter methylation silences PTPRO, contributing to uncontrolled cell proliferation | PMID: 23429703 |
| B-cell lymphoma | PTPRO dephosphorylates SYK, attenuating B-cell receptor signaling; loss of function promotes lymphomagenesis | PMID: 25605246 |
| Chronic lymphocytic leukemia | Reduced PTPRO expression correlates with poor prognosis and enhanced BCR signaling | PMID: 27365425 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Breast | 6.1 | Low |
| Lymph node | 4.7 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| MCF7 | 3.8 | Low expression |
| A549 | 2.5 | Low expression |
| Raji (B-cell lymphoma) | 1.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Truncation, loss of phosphatase domain |
| c.567_568del (p.Glu190fs) | Frameshift | <0.1% | Loss of function |
| c.890A>G (p.Asn297Ser) | Missense | 0.2% | Reduced catalytic activity |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated or absent protein, associated with tumor progression.
Gain of Function (GOF)
No gain-of-function mutations reported in PTPRO.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• B-cell receptor signaling pathway (Reactome: R-HSA-983705)
• EGFR signaling pathway (Reactome: R-HSA-177929)
• STAT3 signaling (Reactome: R-HSA-8950505)
Protein Summary
PTPRO is a 120 kDa transmembrane protein with a single intracellular catalytic phosphatase domain. It is expressed as multiple splice variants. The protein negatively regulates receptor tyrosine kinases and non-receptor kinases such as SYK and STAT3. In cancer, PTPRO is frequently silenced by promoter methylation, leading to enhanced oncogenic signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTPRO Knockout HEK293 Cell Line | EDJ-KQ3699 | Human | 5800 | Details Get a Quote |
| PTPRO Knockout HeLa Cell Line | EDJ-KQ54277 | Human | 5800 | Details Get a Quote |
| PTPRO Knockout A-549 Cell Line | EDJ-KQ62769 | Human | 5800 | Details Get a Quote |
| PTPRO Knockout HCT 116 Cell Line | EDJ-KQ71236 | Human | 5800 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
