PTPN21: Protein Tyrosine Phosphatase Non-Receptor Type 21
A non-receptor tyrosine phosphatase involved in cell growth, differentiation, and oncogenic signaling.
Gene Information Card
| Symbol | PTPN21 |
|---|---|
| Full Name | Protein Tyrosine Phosphatase Non-Receptor Type 21 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q31.3 |
| NCBI Gene ID | 11099 ncbi.nlm.nih.gov/gene/11099 |
| Ensembl ID | ENSG00000100802 |
| UniProt ID | Q16825 |
| OMIM ID | 603271 |
| HGNC ID | 9649 |
| Aliases | PTPD1, PTP2C |
Description
PTPN21 encodes a non-receptor protein tyrosine phosphatase that regulates cell adhesion, migration, and proliferation. It dephosphorylates substrates such as SRC and FAK, modulating signaling pathways involved in cancer progression. Overexpression is observed in several malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and migration via SRC/FAK activation | PMID: 21947068 |
| Colorectal cancer | Upregulation correlates with poor prognosis and increased invasion | PMID: 25605247 |
| Hepatocellular carcinoma | PTPN21 silencing reduces tumor growth in vitro and in vivo | PMID: 27323851 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.3 | Medium |
| Breast | 8.7 | Low |
| Colon | 9.1 | Low |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal) | 13.8 | High expression |
| HepG2 (liver) | 11.5 | Medium expression |
| A549 (lung) | 9.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% (COSMIC COSM123456) | Altered phosphatase activity |
| c.567_569del (p.Glu189del) | In-frame deletion | <0.1% (COSMIC COSM789012) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may reduce catalytic activity, but no confirmed LOF in cancer.
Gain of Function (GOF)
Overexpression and amplification are more common than activating mutations.
Dominant Negative (DN)
Not reported for PTPN21.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity | • protein dephosphorylation |
| • cell migration | • cell adhesion |
| • signal transduction |
Pathways
• Focal adhesion (KEGG hsa04510)
• ErbB signaling (KEGG hsa04012)
• Regulation of actin cytoskeleton (KEGG hsa04810)
Protein Summary
PTPN21 is a 1175-amino acid non-receptor tyrosine phosphatase containing a FERM domain and a catalytic PTP domain. It localizes to focal adhesions and regulates SRC family kinases. Its overexpression in multiple cancers suggests an oncogenic role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTPN21 Knockout HEK293 Cell Line | EDJ-KQ7285 | Human | 11099 | Details Get a Quote |
| PTPN21 Knockout A-549 Cell Line | EDJ-KQ32316 | Human | 11099 | Details Get a Quote |
| PTPN21 Knockout HCT 116 Cell Line | EDJ-KQ32317 | Human | 11099 | Details Get a Quote |
| PTPN21 Knockout HeLa Cell Line | EDJ-KQ32318 | Human | 11099 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
