PTGR1: Prostaglandin Reductase 1 – Gene Overview and Biomedical Significance
Comprehensive gene card, expression, mutations, and disease associations for PTGR1
Gene Information Card
| Symbol | PTGR1 |
|---|---|
| Full Name | Prostaglandin Reductase 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q31.3 |
| NCBI Gene ID | 22949 ncbi.nlm.nih.gov/gene/22949 |
| Ensembl ID | ENSG00000106853 |
| UniProt ID | Q14914 |
| OMIM ID | 601274 |
| HGNC ID | 9590 |
| Aliases | LTB4DH, PGR1, ZADH3 |
Description
PTGR1 encodes prostaglandin reductase 1, an enzyme that catalyzes the NADPH-dependent reduction of prostaglandins and leukotrienes, particularly leukotriene B4 (LTB4). It plays a key role in the inactivation of pro-inflammatory eicosanoids and is involved in lipid metabolism and inflammatory response regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Altered PTGR1 expression may affect prostaglandin metabolism, influencing tumor growth and inflammation. | NCBI Gene, COSMIC |
| Colorectal Cancer | PTGR1 upregulation associated with poor prognosis; potential role in modulating inflammatory tumor microenvironment. | NCBI Gene, COSMIC |
| Inflammatory Diseases | Reduction of LTB4 by PTGR1 dampens neutrophil chemotaxis; dysregulation linked to chronic inflammation. | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small Intestine | 7.1 | Medium |
| Prostate | 6.9 | Medium |
| Colon | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| HEK 293 | 8.7 | Embryonic kidney cells |
| PC-3 | 7.5 | Prostate cancer cell line |
| HT-29 | 6.1 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Potential start codon loss; functional impact unknown |
| c.364C>T | missense | <0.01% | p.Arg122Trp; may affect enzyme activity |
| c.758G>A | missense | <0.01% | p.Arg253His; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Arg122Trp) predicted to reduce catalytic activity based on structural modeling.
Gain of Function (GOF)
No documented gain-of-function mutations in PTGR1.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Prostaglandin Synthesis and Regulation (Reactome: R-HSA-2162123)
• Leukotriene metabolism (Reactome: R-HSA-2142691)
• Arachidonic acid metabolism (KEGG: hsa00590)
Protein Summary
PTGR1 is a 329-amino-acid cytosolic enzyme belonging to the aldo-keto reductase superfamily. It catalyzes the NADPH-dependent reduction of the 13,14-double bond of prostaglandins and leukotrienes, thereby inactivating these lipid mediators. The protein is highly expressed in liver and kidney and plays a critical role in terminating inflammatory signals. Structural studies reveal a typical (α/β)8 barrel fold with a conserved catalytic tetrad.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGR1 Knockout HEK293 Cell Line | EDJ-KQ2066 | Human | 22949 | Details Get a Quote |
| PTGR1 Knockout A-549 Cell Line | EDJ-KQ23508 | Human | 22949 | Details Get a Quote |
| PTGR1 Knockout HCT 116 Cell Line | EDJ-KQ23509 | Human | 22949 | Details Get a Quote |
| PTGR1 Knockout HeLa Cell Line | EDJ-KQ23510 | Human | 22949 | Details Get a Quote |
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