PTGES3L-AARSD1 readthrough (NMD candidate)
A readthrough transcript between PTGES3L and AARSD1, likely subject to nonsense-mediated decay.
Gene Information Card
| Symbol | PTGES3L-AARSD1 |
|---|---|
| Full Name | PTGES3L-AARSD1 readthrough (NMD candidate) |
| Gene Type | readthrough transcript (nonsense-mediated decay candidate) |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 100526835 ncbi.nlm.nih.gov/gene/100526835 |
| Ensembl ID | ENSG00000267508 |
| UniProt ID | - |
| OMIM ID | - |
| HGNC ID | HGNC:48863 |
| Aliases | PTGES3L-AARSD1, PTGES3L-AARSD1 readthrough |
Description
PTGES3L-AARSD1 is a readthrough transcript that spans the PTGES3L and AARSD1 genes on chromosome 17q21.31. This transcript is predicted to be a candidate for nonsense-mediated decay (NMD), meaning it is unlikely to produce a functional protein. The readthrough event may represent a transcriptional or post-transcriptional regulatory mechanism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease associations | - | - |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.1 | Low |
| Other tissues | <0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data available | - | - |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | - | - | - |
Mutation functional classification
Loss of Function (LOF)
Not applicable (NMD candidate)
Gain of Function (GOF)
Not applicable (NMD candidate)
Dominant Negative (DN)
Not applicable (NMD candidate)
View complete mutation data：
Protein Summary
The PTGES3L-AARSD1 readthrough transcript is predicted to undergo nonsense-mediated decay, and therefore no functional protein product is expected. No protein sequence or structure has been curated in UniProt.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGES3L-AARSD1 Knockout HEK293 Cell Line | EDJ-KQ52517 | Human | 100885850 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout HeLa Cell Line | EDJ-KQ60985 | Human | 100885850 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout A-549 Cell Line | EDJ-KQ69459 | Human | 100885850 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout HCT 116 Cell Line | EDJ-KQ77810 | Human | 100885850 | Details Get a Quote |
