PTGES3L Gene - Prostaglandin E Synthase 3 Like
Comprehensive genomic and functional analysis of PTGES3L
Gene Information Card
| Symbol | PTGES3L |
|---|---|
| Full Name | Prostaglandin E Synthase 3 Like |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000267508 |
| UniProt ID | A0A1B0GTV4 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:44584 |
| Aliases | C17orf62, FLJ45831 |
Description
PTGES3L (prostaglandin E synthase 3 like) is a protein-coding gene located on chromosome 17q21.2. It is predicted to be involved in prostaglandin biosynthesis, though its specific biological function remains under investigation. The gene is expressed in various tissues and may play a role in inflammatory processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Thyroid | 0.5 | Low |
| Adrenal gland | 0.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.3 | Low expression |
| K562 | 0.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The PTGES3L protein is predicted to be a member of the prostaglandin E synthase family, but its exact catalytic activity and physiological role have not been experimentally characterized. Sequence similarity suggests it may function in prostaglandin E2 synthesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGES3L Knockout HEK293 Cell Line | EDJ-KQ14954 | Human | 100885848 | Details Get a Quote |
| PTGES3L Knockout HeLa Cell Line | EDJ-KQ44159 | Human | 100885848 | Details Get a Quote |
| PTGES3L Knockout A-549 Cell Line | EDJ-KQ45416 | Human | 100885848 | Details Get a Quote |
| PTGES3L Knockout HCT 116 Cell Line | EDJ-KQ45417 | Human | 100885848 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout HEK293 Cell Line | EDJ-KQ52517 | Human | 100885850 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout HeLa Cell Line | EDJ-KQ60985 | Human | 100885850 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout A-549 Cell Line | EDJ-KQ69459 | Human | 100885850 | Details Get a Quote |
| PTGES3L-AARSD1 Knockout HCT 116 Cell Line | EDJ-KQ77810 | Human | 100885850 | Details Get a Quote |
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