PTGES3 Gene: Prostaglandin E Synthase 3 - Function, Disease, Expression

PTGES3 encodes the cytosolic prostaglandin E synthase (cPGES), also known as p23, which catalyzes the isomerization of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2). It functions as a co-chaperone for Hsp90 and is involved in protein folding, steroid hormone receptor signaling, and inflammatory responses. The gene is ubiquitously expressed and plays roles in cancer, immune regulation, and cellular stress.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Arachidonic acid metabolism

• Prostaglandin synthesis and regulation

• Hsp90 chaperone cycle for steroid hormone receptors (e.g.

• ESR1

• AR)

The PTGES3 protein (cPGES/p23) is a 160-amino acid cytosolic protein that functions both as a prostaglandin E synthase and as a co-chaperone for Hsp90. It contains a p23 domain that binds Hsp90 and facilitates the maturation of client proteins such as steroid hormone receptors and kinases. The enzyme converts PGH2 to PGE2, a key mediator of inflammation and cancer progression. Post-translational modifications include phosphorylation, which modulates its activity.