PTGDR2 (Prostaglandin D2 Receptor 2)
G Protein-Coupled Receptor for Prostaglandin D2 in Allergy and Inflammation
Gene Information Card
| Symbol | PTGDR2 |
|---|---|
| Full Name | Prostaglandin D2 Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 11251 ncbi.nlm.nih.gov/gene/11251 |
| Ensembl ID | ENSG00000183134 |
| UniProt ID | Q9Y5Y4 |
| OMIM ID | 604837 |
| HGNC ID | 9590 |
| Aliases | CRTH2, DL1R, GPR44 |
Description
PTGDR2 (Prostaglandin D2 Receptor 2), also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), is a G protein-coupled receptor that binds prostaglandin D2 (PGD2). It is primarily expressed on Th2 lymphocytes, eosinophils, basophils, and mast cells, and mediates chemotaxis and activation of these cells in allergic inflammation. The receptor couples to Gi-type G proteins, leading to intracellular calcium mobilization and cell migration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | PGD2 binding to PTGDR2 on Th2 cells and eosinophils promotes airway inflammation and bronchoconstriction | ClinVar, OMIM |
| Allergic Rhinitis | Receptor activation enhances eosinophil and basophil recruitment to nasal mucosa | NCBI Gene, OMIM |
| Atopic Dermatitis | PTGDR2 signaling contributes to Th2-driven skin inflammation | OMIM, ClinVar |
| Eosinophilic Esophagitis | Overexpression of PTGDR2 on eosinophils correlates with disease severity | NCBI Gene |
| Chronic Urticaria | PGD2/PTGDR2 axis implicated in mast cell activation and pruritus | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole Blood | 0.0 | Not detected |
| Lung | 0.3 | Low |
| Spleen | 0.1 | Low |
| Bone Marrow | 0.2 | Low |
| Small Intestine | 0.1 | Low |
| Colon | 0.1 | Low |
| Adipose Tissue | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Th2 lymphocytes | High | Key functional expression |
| Eosinophils | High | Mediates chemotaxis |
| Basophils | High | Histamine release |
| Mast cells | Moderate | PGD2 feedback |
| Monocytes | Low | Minor expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.154G>A (p.Gly52Arg) | Missense | Rare | Unknown functional impact |
| c.200C>T (p.Pro67Leu) | Missense | Rare | Unknown functional impact |
| c.301A>G (p.Ile101Val) | Missense | Rare | Unknown functional impact |
| c.454G>A (p.Val152Met) | Missense | Rare | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • prostaglandin D receptor activity |
| • chemokine receptor activity | • cell surface receptor signaling pathway |
| • inflammatory response | • immune response |
| • chemotaxis | • positive regulation of cytosolic calcium ion concentration |
| • G protein-coupled receptor signaling pathway | • coupled to cyclic nucleotide second messenger |
Pathways
• Prostanoid ligand receptors (Reactome: R-HSA-416476)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• PGD2/PTGDR2 signaling in allergic response (KEGG: hsa04726)
Protein Summary
The PTGDR2 protein (UniProt Q9Y5Y4) is a 398-amino acid G protein-coupled receptor with seven transmembrane domains. It is expressed on Th2 cells, eosinophils, basophils, and mast cells. Upon binding prostaglandin D2, it activates Gi-type G proteins, leading to calcium mobilization, chemotaxis, and cytokine release. It plays a central role in allergic inflammation and is a therapeutic target for asthma and allergic rhinitis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGDR2 Knockout HEK293 Cell Line | EDJ-KQ51057 | Human | 11251 | Details Get a Quote |
| PTGDR2 Knockout HeLa Cell Line | EDJ-KQ55612 | Human | 11251 | Details Get a Quote |
| PTGDR2 Knockout A-549 Cell Line | EDJ-KQ64111 | Human | 11251 | Details Get a Quote |
| PTGDR2 Knockout HCT 116 Cell Line | EDJ-KQ72556 | Human | 11251 | Details Get a Quote |
