PTGDR Gene - Prostaglandin D2 Receptor
GPCR for PGD2 in allergy, asthma, and immune regulation
Gene Information Card
| Symbol | PTGDR |
|---|---|
| Full Name | prostaglandin D2 receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 14q22.1 |
| NCBI Gene ID | 5729 ncbi.nlm.nih.gov/gene/5729 |
| Ensembl ID | ENSG00000168229 |
| UniProt ID | Q13258 |
| OMIM ID | 604687 |
| HGNC ID | 9594 |
| Aliases | DP1, DP, PTGDR1, AS1, DP receptor |
Description
The PTGDR gene encodes the prostaglandin D2 receptor (DP1), a G protein-coupled receptor that binds prostaglandin D2 (PGD2). It is involved in allergic and inflammatory responses, smooth muscle contraction, and immune cell chemotaxis. Activation of DP1 leads to increased intracellular cAMP levels. The gene is expressed in various tissues including lung, placenta, and immune cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | PTGDR variants alter receptor expression and signaling, affecting bronchoconstriction and airway inflammation. | ClinVar, OMIM |
| Allergic rhinitis | PGD2-DP1 signaling promotes Th2 inflammation and nasal congestion. | NCBI Gene, OMIM |
| Atopic dermatitis | DP1 activation in skin contributes to pruritus and inflammation. | UniProt, ClinVar |
| Systemic mastocytosis | Increased PGD2 release from mast cells activates DP1, causing flushing and hypotension. | OMIM, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Placenta | 8.3 | Low |
| Spleen | 6.1 | Low |
| Small intestine | 4.7 | Low |
| Trachea | 15.2 | Medium |
| Bone marrow | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| A549 | 2.1 | Low expression |
| THP-1 | 5.4 | Moderate expression |
| Jurkat | 1.2 | Low expression |
| HUVEC | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.−666C>T | SNP | 0.15 (allele frequency) | Associated with reduced promoter activity and asthma risk |
| c.−197T>C | SNP | 0.22 | Alters transcription factor binding, linked to allergic rhinitis |
| p.Arg120Cys | missense | <0.01 | Reduced receptor function in vitro |
| p.Leu251Phe | missense | <0.01 | Impaired ligand binding |
Mutation functional classification
Loss of Function (LOF)
c.−666C>T and p.Arg120Cys reduce receptor expression or signaling, associated with asthma susceptibility.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PTGDR.
Dominant Negative (DN)
No dominant-negative mutations described for PTGDR.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • prostaglandin D receptor activity |
| • prostaglandin binding | • adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| • inflammatory response | • smooth muscle contraction |
| • chemotaxis |
Pathways
• Prostanoid ligand-receptor interaction
• GPCR downstream signaling (cAMP)
• Allergic inflammation (Th2 response)
Protein Summary
The PTGDR protein (DP1 receptor) is a 359-amino-acid G protein-coupled receptor with seven transmembrane domains. It binds prostaglandin D2 with high affinity and couples primarily to Gs, increasing cAMP. DP1 is expressed on Th2 cells, eosinophils, basophils, and smooth muscle cells, mediating chemotaxis, vasodilation, and bronchoconstriction. It is a therapeutic target for allergic asthma and rhinitis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PTGDR Knockout HEK293 Cell Line | EDJ-KQ5582 | Human | 5729 | Details Get a Quote |
| PTGDR2 Knockout HEK293 Cell Line | EDJ-KQ51057 | Human | 11251 | Details Get a Quote |
| PTGDR Knockout HeLa Cell Line | EDJ-KQ54254 | Human | 5729 | Details Get a Quote |
| PTGDR2 Knockout HeLa Cell Line | EDJ-KQ55612 | Human | 11251 | Details Get a Quote |
| PTGDR Knockout A-549 Cell Line | EDJ-KQ62745 | Human | 5729 | Details Get a Quote |
| PTGDR2 Knockout A-549 Cell Line | EDJ-KQ64111 | Human | 11251 | Details Get a Quote |
| PTGDR Knockout HCT 116 Cell Line | EDJ-KQ71214 | Human | 5729 | Details Get a Quote |
| PTGDR2 Knockout HCT 116 Cell Line | EDJ-KQ72556 | Human | 11251 | Details Get a Quote |
