PSME3: Proteasome Activator Subunit 3
A key regulator of proteasome function and cellular proteostasis, implicated in cancer and immune response.
Gene Information Card
| Symbol | PSME3 |
|---|---|
| Full Name | Proteasome activator subunit 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 10197 ncbi.nlm.nih.gov/gene/10197 |
| Ensembl ID | ENSG00000131467 |
| UniProt ID | P61289 |
| OMIM ID | 605129 |
| HGNC ID | 9569 |
| Aliases | PA28γ, REG-gamma, Ki nuclear autoantigen |
Description
PSME3 encodes a member of the proteasome activator family, specifically the PA28 gamma subunit. This protein is a nuclear activator of the 20S proteasome, involved in ubiquitin-independent protein degradation. It plays roles in cell cycle regulation, apoptosis, and immune response. Overexpression is linked to various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PSME3 overexpression promotes cell proliferation and inhibits apoptosis via p53 degradation. | PMID: 23455478 |
| Colorectal cancer | PSME3 upregulation correlates with poor prognosis and enhances tumor growth. | PMID: 25636847 |
| Hepatocellular carcinoma | PSME3 activates proteasomal degradation of p21 and p27, driving cell cycle progression. | PMID: 27323851 |
| Lung cancer | PSME3 expression is elevated and associated with metastasis. | PMID: 28692042 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Lymph node | 10.2 | High |
| Spleen | 9.8 | High |
| Bone marrow | 8.5 | Medium |
| Brain | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.1 | Cervical cancer cell line |
| K562 | 11.3 | Leukemia cell line |
| A549 | 9.7 | Lung cancer cell line |
| MCF7 | 8.9 | Breast cancer cell line |
| HEK293 | 7.5 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.637C>T (p.Arg213Trp) | Missense | <0.01% | Unknown functional impact |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Likely loss of function |
| c.1045_1046insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare start-loss and frameshift variants likely result in loss of PSME3 function, impairing proteasome activation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PSME3.
Dominant Negative (DN)
No dominant-negative mutations described for PSME3.
View complete mutation data：
Gene Ontology (GO)
| • proteasome complex (GO:0000502) | • proteasome activator activity (GO:0008538) |
| • ubiquitin-dependent protein catabolic process (GO:0006511) | • proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) |
| • nucleus (GO:0005634) |
Pathways
• Proteasome degradation (Reactome: R-HSA-983168)
• Antigen processing and presentation (KEGG: hsa04612)
• p53 signaling pathway (KEGG: hsa04115)
Protein Summary
PSME3 (PA28γ) is a nuclear protein that binds and activates the 20S proteasome, facilitating the degradation of proteins such as p53, p21, and p27 in a ubiquitin-independent manner. It is highly expressed in testis and lymphoid tissues, and its overexpression in cancers contributes to tumor progression by promoting cell cycle progression and inhibiting apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PSME3IP1 Knockout HEK293 Cell Line | EDJ-KQ9425 | Human | 80011 | Details Get a Quote |
| PSME3IP1 Knockout A-549 Cell Line | EDJ-KQ36081 | Human | 80011 | Details Get a Quote |
| PSME3IP1 Knockout HCT 116 Cell Line | EDJ-KQ36082 | Human | 80011 | Details Get a Quote |
| PSME3IP1 Knockout HeLa Cell Line | EDJ-KQ34836 | Human | 80011 | Details Get a Quote |
| PSME3 Knockout HEK293 Cell Line | EDJ-KQ50941 | Human | 10197 | Details Get a Quote |
| PSME3 Knockout HeLa Cell Line | EDJ-KQ55342 | Human | 10197 | Details Get a Quote |
| PSME3 Knockout A-549 Cell Line | EDJ-KQ63822 | Human | 10197 | Details Get a Quote |
| PSME3 Knockout HCT 116 Cell Line | EDJ-KQ72284 | Human | 10197 | Details Get a Quote |
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