PRXL2C Gene (Peroxiredoxin-Like 2C): Genetic Information, Expression, and Clinical Significance
Comprehensive biomedical resource for PRXL2C, including genomic context, protein function, tissue expression, and disease associations.
Gene Information Card
| Symbol | PRXL2C |
|---|---|
| Full Name | Peroxiredoxin-like 2C |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q24.3 |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000269335 |
| UniProt ID | A0A1B0GVR6 |
| OMIM ID | Not available |
| HGNC ID | HGNC:44216 |
| Aliases | PRXL2C, peroxiredoxin like 2C |
Description
PRXL2C (Peroxiredoxin-like 2C) is a protein-coding gene located on chromosome 1q24.3. It encodes a protein that shares sequence similarity with peroxiredoxins, a family of antioxidant enzymes, but its exact function remains to be fully characterized. The gene is expressed in various tissues, with notable levels in the thyroid and adrenal glands. PRXL2C has been implicated in certain cancers and metabolic conditions, though detailed mechanistic studies are ongoing.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Thyroid cancer | Potential involvement in oxidative stress response; altered expression may contribute to tumorigenesis. | Expression data from GTEx and literature |
| Adrenal gland disorders | High expression in adrenal tissue suggests a role in adrenal function; dysregulation may be linked to adrenal pathologies. | Expression data from GTEx |
| Metabolic syndrome | Possible association with oxidative stress and metabolic regulation, but evidence is preliminary. | Limited studies; further research needed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 12.3 | High |
| Adrenal gland | 10.8 | High |
| Kidney | 5.2 | Medium |
| Liver | 3.1 | Low |
| Brain | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 8.4 | Moderate expression |
| A549 | 6.2 | Moderate expression |
| MCF7 | 4.1 | Low expression |
| K562 | 2.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs123456 (example) | SNV | 0.5% | Potential impact on protein stability; clinical significance unknown |
| c.123A>G (example) | Missense | 0.1% | May alter protein function; not yet characterized |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported for PRXL2C.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: antioxidant activity (inferred from sequence similarity) | • Biological process: cellular response to oxidative stress (inferred from sequence similarity) |
| • Cellular component: cytoplasm (inferred from sequence similarity) |
Pathways
• Reactive oxygen species (ROS) metabolism (inferred from peroxiredoxin similarity)
• Oxidative stress response (inferred)
Protein Summary
The PRXL2C protein is predicted to be a cytoplasmic protein with a thioredoxin-like fold, characteristic of the peroxiredoxin family. It may participate in reducing peroxides and protecting cells from oxidative damage, but its specific substrates and physiological roles are not yet defined. Further experimental validation is required to confirm its enzymatic activity and interaction partners.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRXL2C Knockout HEK293 Cell Line | EDJ-KQ14943 | Human | 195827 | Details Get a Quote |
| PRXL2C Knockout HCT 116 Cell Line | EDJ-KQ44140 | Human | 195827 | Details Get a Quote |
| PRXL2C Knockout A-549 Cell Line | EDJ-KQ45398 | Human | 195827 | Details Get a Quote |
| PRXL2C Knockout HeLa Cell Line | EDJ-KQ45399 | Human | 195827 | Details Get a Quote |
