PRXL2B
Peroxiredoxin Like 2B
Gene Information Card
| Symbol | PRXL2B |
|---|---|
| Full Name | Peroxiredoxin Like 2B |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 100129917 ncbi.nlm.nih.gov/gene/100129917 |
| Ensembl ID | ENSG00000203782 |
| UniProt ID | A6NHR9 |
| OMIM ID | not available |
| HGNC ID | HGNC:37207 |
| Aliases | PRXL2B, MGC16384 |
Description
PRXL2B (Peroxiredoxin Like 2B) is a protein-coding gene located on chromosome 1p36.33. The encoded protein belongs to the peroxiredoxin-like family, which may be involved in redox regulation. Limited functional data are available; expression is detected in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| not established | not established | no evidence in ClinVar or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| testis | 5.2 | low |
| brain | 3.1 | low |
| lung | 2.8 | low |
| kidney | 2.5 | low |
| liver | 1.9 | low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.0 | low expression |
| HeLa | 3.5 | low expression |
| K562 | 2.1 | low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| not reported | not applicable | not applicable | not applicable |
Mutation functional classification
Loss of Function (LOF)
not characterized
Gain of Function (GOF)
not characterized
Dominant Negative (DN)
not characterized
View complete mutation data：
Protein Summary
The PRXL2B protein (UniProt A6NHR9) is a 142-amino acid polypeptide with a thioredoxin-like fold. Its exact function is unknown, but it may participate in cellular redox homeostasis based on sequence similarity to peroxiredoxins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRXL2B Knockout HEK293 Cell Line | EDJ-KQ9028 | Human | 127281 | Details Get a Quote |
| PRXL2B Knockout HeLa Cell Line | EDJ-KQ34218 | Human | 127281 | Details Get a Quote |
| PRXL2B Knockout A-549 Cell Line | EDJ-KQ35468 | Human | 127281 | Details Get a Quote |
| PRXL2B Knockout HCT 116 Cell Line | EDJ-KQ35469 | Human | 127281 | Details Get a Quote |
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