PRXL2A
Peroxiredoxin-Like 2A
Gene Information Card
| Symbol | PRXL2A |
|---|---|
| Full Name | Peroxiredoxin-Like 2A |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 100131801 ncbi.nlm.nih.gov/gene/100131801 |
| Ensembl ID | ENSG00000203782 |
| UniProt ID | Q6P1Q0 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:44538 |
| Aliases | PRXL2A, FLJ46361 |
Description
PRXL2A (Peroxiredoxin-Like 2A) is a protein-coding gene located on chromosome 1q21.3. The encoded protein belongs to the peroxiredoxin-like family, which is involved in cellular antioxidant defense mechanisms. PRXL2A is predicted to play a role in redox regulation and protection against oxidative stress. Expression data indicate broad tissue distribution with highest levels in the thyroid and adrenal glands.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 12.5 | Medium |
| Adrenal gland | 10.2 | Medium |
| Testis | 8.7 | Low |
| Kidney | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Moderate expression |
| HeLa | 7.2 | Low expression |
| K562 | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • antioxidant activity | • peroxiredoxin activity |
| • oxidoreductase activity |
Pathways
• No curated pathways
Protein Summary
The PRXL2A protein is a member of the peroxiredoxin-like family, characterized by a conserved thioredoxin fold. It is predicted to function as an antioxidant enzyme, reducing hydrogen peroxide and organic hydroperoxides. The protein is localized to the cytoplasm and may participate in cellular redox homeostasis. Structural analysis suggests a 2-Cys peroxiredoxin mechanism, though functional validation is limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRXL2A Knockout HEK293 Cell Line | EDJ-KQ10055 | Human | 84293 | Details Get a Quote |
| PRXL2A Knockout A-549 Cell Line | EDJ-KQ37092 | Human | 84293 | Details Get a Quote |
| PRXL2A Knockout HeLa Cell Line | EDJ-KQ37094 | Human | 84293 | Details Get a Quote |
| PRXL2A Knockout HCT 116 Cell Line | EDJ-KQ35869 | Human | 84293 | Details Get a Quote |
