PRSS41 (Serine Protease 41)
A trypsin-like serine protease gene with potential roles in spermatogenesis and cancer.
Gene Information Card
| Symbol | PRSS41 |
|---|---|
| Full Name | serine protease 41 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 360226 ncbi.nlm.nih.gov/gene/360226 |
| Ensembl ID | ENSG00000196476 |
| UniProt ID | Q8N7Z2 |
| OMIM ID | 614578 |
| HGNC ID | 34403 |
| Aliases | TMTSP3, testis-specific transmembrane serine protease 3 |
Description
PRSS41 encodes a serine protease of the trypsin family, predominantly expressed in testis. The protein contains a transmembrane domain and is predicted to function in proteolytic processing during spermatogenesis. Limited functional studies suggest a role in male fertility. The gene is located on chromosome 16p13.3 and is conserved in mammals.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Potential dysregulation of serine protease activity in tumor microenvironment | COSMIC: mutations observed in prostate cancer samples |
| Colorectal cancer | Somatic mutations reported; functional impact unknown | COSMIC: missense mutations in colorectal adenocarcinoma |
| Lung cancer | Rare mutations detected; no established mechanism | COSMIC: non-synonymous variants in lung carcinoma |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 1.2 | Low |
| Lung | 0.8 | Low |
| Colon | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NCI-H1299 (lung) | 0.3 | Low expression |
| PC-3 (prostate) | 0.6 | Low expression |
| HT-29 (colon) | 0.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104G>A (p.Arg35Gln) | Missense | 0.02% (COSMIC) | Unknown; predicted benign |
| c.287C>T (p.Pro96Leu) | Missense | 0.01% (COSMIC) | Unknown; predicted possibly damaging |
| c.421A>G (p.Ile141Val) | Missense | 0.01% (COSMIC) | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PRSS41.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • proteolysis (GO:0006508) |
| • integral component of membrane (GO:0016021) | • spermatogenesis (GO:0007283) |
Pathways
• No specific pathways curated for PRSS41 in Reactome or KEGG.
Protein Summary
PRSS41 is a 359-amino acid transmembrane serine protease with a trypsin-like catalytic domain. It is predicted to be synthesized as a zymogen and activated by proteolytic cleavage. The protein is primarily expressed in testis and may participate in extracellular matrix remodeling or cell signaling during sperm maturation. Structural homology suggests a substrate preference for basic amino acids (trypsin-like).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS41 Knockout HEK293 Cell Line | EDJ-KQ11490 | Human | 360226 | Details Get a Quote |
| PRSS41 Knockout HeLa Cell Line | EDJ-KQ59888 | Human | 360226 | Details Get a Quote |
| PRSS41 Knockout A-549 Cell Line | EDJ-KQ68351 | Human | 360226 | Details Get a Quote |
| PRSS41 Knockout HCT 116 Cell Line | EDJ-KQ76727 | Human | 360226 | Details Get a Quote |
