PRSS38
Serine Protease 38: A Trypsin-like Protease with Limited Functional Annotation
Gene Information Card
| Symbol | PRSS38 |
|---|---|
| Full Name | Serine Protease 38 |
| Gene Type | Protein-coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000214595 |
| UniProt ID | A6NKD9 |
| OMIM ID | Not assigned |
| HGNC ID | 33796 |
| Aliases | MGC129935, MGC129936 |
Description
PRSS38 (Serine Protease 38) is a protein-coding gene located on chromosome 17q21.31. It encodes a member of the trypsin-like serine protease family, characterized by a conserved catalytic triad of histidine, aspartate, and serine residues. The gene is predicted to be involved in proteolysis and may play a role in extracellular matrix remodeling or digestive processes. Currently, its biological function is not fully characterized, and no direct disease associations have been established in major databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.3 | Low |
| Skin | 0.1 | Low |
| Lung | 0.1 | Low |
| Thyroid | 0.1 | Low |
| Prostate | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low expression |
| K-562 | 0.1 | Low expression |
| HeLa | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | No known pathogenic or somatic mutations in ClinVar or COSMIC |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • proteolysis (GO:0006508) |
| • extracellular region (GO:0005576) |
Protein Summary
The PRSS38 protein (UniProt A6NKD9) is a predicted serine protease of the trypsin family, containing a signal peptide and a trypsin-like domain. It is synthesized as a zymogen and likely activated by proteolytic cleavage. The protein is predicted to be secreted or localized to the extracellular space. Its specific substrates and physiological roles remain unknown, and no crystal structure has been determined.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS38 Knockout HEK293 Cell Line | EDJ-KQ14935 | Human | 339501 | Details Get a Quote |
| PRSS38 Knockout HeLa Cell Line | EDJ-KQ59645 | Human | 339501 | Details Get a Quote |
| PRSS38 Knockout A-549 Cell Line | EDJ-KQ68114 | Human | 339501 | Details Get a Quote |
| PRSS38 Knockout HCT 116 Cell Line | EDJ-KQ76489 | Human | 339501 | Details Get a Quote |
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