PRSS36: Serine Protease 36
A transmembrane serine protease with potential roles in extracellular matrix remodeling and cancer progression.
Gene Information Card
| Symbol | PRSS36 |
|---|---|
| Full Name | serine protease 36 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 146547 ncbi.nlm.nih.gov/gene/146547 |
| Ensembl ID | ENSG00000161921 |
| UniProt ID | Q6UWY2 |
| OMIM ID | 617169 |
| HGNC ID | 28958 |
| Aliases | MSPL, TMPRSS36, DESC7 |
Description
PRSS36 (serine protease 36) is a protein-coding gene located on chromosome 16p11.2. It encodes a member of the type II transmembrane serine protease (TTSP) family, characterized by a transmembrane domain and a serine protease domain. The protein is involved in proteolytic processing of extracellular matrix components and activation of signaling pathways. PRSS36 is expressed in various tissues and has been implicated in cancer progression and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression may promote tumor invasion and metastasis through ECM degradation and activation of protease-activated receptors. | Limited evidence from expression studies and in vitro assays; no large-scale clinical validation. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 15.2 | Medium |
| Esophagus | 12.8 | Medium |
| Prostate | 10.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocytes) | 18.4 | High expression in skin-derived cells |
| A549 (lung cancer) | 9.1 | Moderate expression |
| MCF7 (breast cancer) | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045G>A (p.Gly349Arg) | Missense | 0.01% (gnomAD) | Unknown functional impact; predicted benign by SIFT/PolyPhen |
| c.1237C>T (p.Arg413Trp) | Missense | 0.005% (gnomAD) | Unknown functional impact; predicted possibly damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • plasma membrane (GO:0005886) |
| • proteolysis (GO:0006508) | • integral component of membrane (GO:0016021) |
| • extracellular matrix (GO:0031012) |
Pathways
• Proteolysis and extracellular matrix remodeling
• Activation of protease-activated receptors (PARs) signaling
Protein Summary
The PRSS36 protein (UniProt Q6UWY2) is a 548-amino-acid type II transmembrane serine protease. It contains a short cytoplasmic N-terminal domain, a transmembrane helix, a LDL receptor class A domain, a scavenger receptor cysteine-rich domain, and a C-terminal serine protease domain with the catalytic triad His-Asp-Ser. The protein is synthesized as a zymogen and activated by proteolytic cleavage. It is localized to the plasma membrane and can be shed into the extracellular space. Its proteolytic activity targets extracellular matrix components and may activate signaling cascades involved in cell migration and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS36 Knockout HEK293 Cell Line | EDJ-KQ10485 | Human | 146547 | Details Get a Quote |
| PRSS36 Knockout HeLa Cell Line | EDJ-KQ37881 | Human | 146547 | Details Get a Quote |
| PRSS36 Knockout A-549 Cell Line | EDJ-KQ67038 | Human | 146547 | Details Get a Quote |
| PRSS36 Knockout HCT 116 Cell Line | EDJ-KQ75438 | Human | 146547 | Details Get a Quote |
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