PRSS35: Serine Protease 35
A secreted serine protease with roles in adipogenesis, ovarian function, and potential implications in metabolic and reproductive disorders.
Gene Information Card
| Symbol | PRSS35 |
|---|---|
| Full Name | Serine Protease 35 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q14.1 |
| NCBI Gene ID | 167681 ncbi.nlm.nih.gov/gene/167681 |
| Ensembl ID | ENSG00000146250 |
| UniProt ID | Q8N3Z0 |
| OMIM ID | 614523 |
| HGNC ID | 18423 |
| Aliases | MCPT-7, MCPT7, PRSS35_HUMAN |
Description
PRSS35 encodes a member of the serine protease family, specifically a trypsin-like serine protease. The protein is secreted and has been implicated in adipocyte differentiation (adipogenesis) and ovarian follicle development. It is expressed in various tissues, with notable levels in adipose tissue and ovary. PRSS35 may play a role in extracellular matrix remodeling and proteolytic processing of signaling molecules.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian insufficiency | PRSS35 variants may disrupt ovarian follicle development, leading to premature ovarian failure. | ClinVar, OMIM |
| Metabolic syndrome | Altered PRSS35 expression in adipose tissue may affect adipogenesis and insulin sensitivity. | NCBI Gene, UniProt |
| Endometriosis | Differential expression of PRSS35 in endometrial tissues suggests a role in endometrial function. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 15.2 | Medium |
| Ovary | 12.8 | Medium |
| Testis | 8.5 | Low |
| Lung | 6.1 | Low |
| Kidney | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Adipocytes (differentiated) | 18.5 | High expression during adipogenesis |
| Ovarian granulosa cells | 14.0 | Relevant to follicle development |
| Endometrial stromal cells | 9.2 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Likely loss of function; associated with ovarian insufficiency |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown significance; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function variants in PRSS35 are associated with impaired adipogenesis and ovarian dysfunction, likely due to reduced proteolytic activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for PRSS35.
Dominant Negative (DN)
No dominant-negative effects have been described for PRSS35.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • extracellular region (GO:0005576) |
| • proteolysis (GO:0006508) | • cell differentiation (GO:0030154) |
| • fat cell differentiation (GO:0045444) |
Pathways
• Adipogenesis pathway (Reactome: R-HSA-381340)
• Extracellular matrix organization (Reactome: R-HSA-1474244)
Protein Summary
PRSS35 is a secreted serine protease of the trypsin family. The protein is synthesized as a zymogen and activated by proteolytic cleavage. It is involved in extracellular matrix remodeling and proteolytic processing during adipogenesis and ovarian follicle development. Structural analysis reveals a typical serine protease catalytic triad (His, Asp, Ser).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS35 Knockout HEK293 Cell Line | EDJ-KQ14934 | Human | 167681 | Details Get a Quote |
| PRSS35 Knockout A-549 Cell Line | EDJ-KQ45381 | Human | 167681 | Details Get a Quote |
| PRSS35 Knockout HeLa Cell Line | EDJ-KQ58906 | Human | 167681 | Details Get a Quote |
| PRSS35 Knockout HCT 116 Cell Line | EDJ-KQ75788 | Human | 167681 | Details Get a Quote |
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