PRSS27 (Serine Protease 27)
A trypsin-like serine protease with potential roles in cancer and immune regulation
Gene Information Card
| Symbol | PRSS27 |
|---|---|
| Full Name | Serine Protease 27 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 83886 ncbi.nlm.nih.gov/gene/83886 |
| Ensembl ID | ENSG00000161921 |
| UniProt ID | Q9BQR3 |
| OMIM ID | 612062 |
| HGNC ID | 17883 |
| Aliases | MCPT-7, MCPT7, tryptase-7, serine protease 27 |
Description
PRSS27 (serine protease 27) encodes a trypsin-like serine protease belonging to the S1 family. The protein is predicted to function in proteolytic processing and may play roles in immune responses and tumor biology. Expression is enriched in certain immune cells and epithelial tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Potential involvement in tumor microenvironment remodeling via extracellular matrix degradation | Limited evidence from expression studies (PMID: 25944712) |
| Inflammatory bowel disease | Possible role in mucosal immune regulation | Expression changes observed in colonic biopsies (PMID: 20628086) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Small intestine | 8.3 | Medium |
| Colon | 6.1 | Low |
| Lung | 4.2 | Low |
| Spleen | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic cancer) | 15.2 | Highest among tested lines |
| Caco-2 (colorectal) | 9.8 | Moderate |
| A549 (lung) | 5.1 | Low |
| HEK293 (embryonic kidney) | 2.3 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.431G>A (p.Arg144His) | Missense | <0.01% in gnomAD | Unknown functional impact |
| c.682C>T (p.Arg228Trp) | Missense | <0.01% in gnomAD | Predicted damaging (SIFT) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • proteolysis (GO:0006508) |
| • extracellular region (GO:0005576) | • extracellular space (GO:0005615) |
Pathways
• Proteolysis and extracellular matrix remodeling (Reactome: R-HSA-1474228)
• Degradation of the extracellular matrix (Reactome: R-HSA-1474228)
Protein Summary
Serine protease 27 (UniProt Q9BQR3) is a 317-amino acid protein with a trypsin-like serine protease domain. It contains a signal peptide for secretion and is predicted to be active in the extracellular space. The protein may participate in proteolytic cascades relevant to inflammation and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS27 Knockout HEK293 Cell Line | EDJ-KQ9920 | Human | 83886 | Details Get a Quote |
| PRSS27 Knockout HeLa Cell Line | EDJ-KQ57495 | Human | 83886 | Details Get a Quote |
| PRSS27 Knockout A-549 Cell Line | EDJ-KQ65998 | Human | 83886 | Details Get a Quote |
| PRSS27 Knockout HCT 116 Cell Line | EDJ-KQ74421 | Human | 83886 | Details Get a Quote |
