PRSS23
Serine Protease 23: A Transmembrane Protease Involved in Development and Cancer
Gene Information Card
| Symbol | PRSS23 |
|---|---|
| Full Name | serine protease 23 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q14.1 |
| NCBI Gene ID | 11098 ncbi.nlm.nih.gov/gene/11098 |
| Ensembl ID | ENSG00000150687 |
| UniProt ID | Q9NQ84 |
| OMIM ID | 617590 |
| HGNC ID | 14370 |
| Aliases | SPUVE, ZSIG13, UNQ188/PRO214 |
Description
PRSS23 encodes a member of the trypsin family of serine proteases. The protein is a type II transmembrane serine protease, characterized by a short cytoplasmic domain, a transmembrane domain, and an extracellular serine protease domain. It is involved in extracellular matrix remodeling, cell migration, and developmental processes. PRSS23 is expressed in various tissues and has been implicated in cancer progression, particularly in ovarian, breast, and gastric cancers, as well as in embryonic development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian cancer | Overexpression promotes cell proliferation and invasion via ECM degradation | PMID: 25636840 |
| Breast cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 27323851 |
| Gastric cancer | High expression associated with tumor stage and lymph node metastasis | PMID: 28352258 |
| Endometriosis | Dysregulated expression in ectopic endometrial tissue | PMID: 21933870 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Ovary | 12.5 | Medium |
| Breast | 8.3 | Low |
| Stomach | 15.2 | Medium |
| Placenta | 20.1 | High |
| Lung | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | Cervical cancer cell line |
| MCF7 | 22.1 | Breast cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| OVCAR-3 | 35.6 | Ovarian cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015G>A (p.Gly339Arg) | Missense | <0.01% | Unknown functional impact |
| c.1247C>T (p.Thr416Met) | Missense | <0.01% | Reported in COSMIC as somatic in colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role, but no specific activating mutations documented.
Dominant Negative (DN)
No evidence for dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity | • proteolysis |
| • extracellular matrix disassembly | • cell migration |
| • membrane |
Pathways
• Extracellular matrix organization
• Proteolysis
Protein Summary
PRSS23 is a 438-amino acid type II transmembrane serine protease with a signal peptide, a transmembrane domain, and a trypsin-like serine protease domain. It is synthesized as a zymogen and activated by proteolytic cleavage. The protein localizes to the cell surface and is involved in pericellular proteolysis, facilitating cell migration and tissue remodeling. Its expression is regulated during development and in pathological conditions such as cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS23 Knockout HEK293 Cell Line | EDJ-KQ2267 | Human | 11098 | Details Get a Quote |
| PRSS23 Knockout A-549 Cell Line | EDJ-KQ22604 | Human | 11098 | Details Get a Quote |
| PRSS23 Knockout HCT 116 Cell Line | EDJ-KQ22605 | Human | 11098 | Details Get a Quote |
| PRSS23 Knockout HeLa Cell Line | EDJ-KQ22606 | Human | 11098 | Details Get a Quote |
