PRSS22: Serine Protease 22 – Structure, Function, and Clinical Relevance
Comprehensive genomic and proteomic overview of PRSS22 (serine protease 22) with expression, mutation, and disease association data.
Gene Information Card
| Symbol | PRSS22 |
|---|---|
| Full Name | serine protease 22 |
| Gene Type | protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 64063 ncbi.nlm.nih.gov/gene/64063 |
| Ensembl ID | ENSG00000140937 |
| UniProt ID | Q9GZN4 |
| OMIM ID | 609343 |
| HGNC ID | 9476 |
| Aliases | SP001LA, TMPRSS2L, PRSS22 |
Description
PRSS22 (serine protease 22) is a protein-coding gene located on chromosome 16p13.3. It encodes a member of the serine protease family, characterized by a trypsin-like serine protease domain. The protein is involved in proteolytic processing and may play roles in extracellular matrix remodeling, cell signaling, and immune responses. PRSS22 is expressed in various tissues, with notable levels in the respiratory tract and gastrointestinal system. Alterations in PRSS22 expression have been implicated in certain cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | PRSS22 overexpression may contribute to airway remodeling and inflammation via protease-activated receptor (PAR) signaling. | PMID: 20628086 |
| Colorectal cancer | Upregulation of PRSS22 in tumor tissues suggests a role in tumor progression and metastasis. | PMID: 23542379 |
| Prostate cancer | PRSS22 expression is altered in prostate cancer, potentially affecting tumor microenvironment. | PMID: 24120478 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Trachea | 15.2 | Medium |
| Colon | 8.3 | Low |
| Small intestine | 7.1 | Low |
| Prostate | 6.8 | Low |
| Skin | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 18.4 | High expression |
| Caco-2 (colorectal adenocarcinoma) | 9.7 | Moderate expression |
| PC-3 (prostate cancer) | 7.2 | Low expression |
| HEK 293 (embryonic kidney) | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347G>A (p.Arg116His) | Missense | 0.02% (gnomAD) | Unknown functional impact; located in serine protease domain |
| c.523C>T (p.Pro175Ser) | Missense | 0.01% (gnomAD) | May affect protein stability |
| c.788_789insA (p.Tyr263Ter) | Frameshift | Rare | Predicted loss-of-function via premature stop codon |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Tyr263Ter) are predicted to cause loss of protease activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PRSS22.
Dominant Negative (DN)
No evidence for dominant-negative effects in PRSS22.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • proteolysis (GO:0006508) |
| • extracellular region (GO:0005576) | • plasma membrane (GO:0005886) |
| • integral component of membrane (GO:0016021) |
Pathways
• Proteolysis and extracellular matrix remodeling
• PAR (protease-activated receptor) signaling pathway
Protein Summary
PRSS22 encodes a 317-amino acid serine protease with a signal peptide, a transmembrane domain, and a trypsin-like serine protease domain (S1 family). The protein is synthesized as a zymogen and activated by proteolytic cleavage. It localizes to the plasma membrane and extracellular space, where it cleaves substrates involved in cell adhesion, migration, and inflammation. PRSS22 is structurally similar to other type II transmembrane serine proteases (TTSPs) such as TMPRSS2.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRSS22 Knockout HEK293 Cell Line | EDJ-KQ14931 | Human | 64063 | Details Get a Quote |
| PRSS22 Knockout HCT 116 Cell Line | EDJ-KQ44121 | Human | 64063 | Details Get a Quote |
| PRSS22 Knockout HeLa Cell Line | EDJ-KQ57012 | Human | 64063 | Details Get a Quote |
| PRSS22 Knockout A-549 Cell Line | EDJ-KQ65518 | Human | 64063 | Details Get a Quote |
