PRR5L
Proline Rich 5 Like
Gene Information Card
| Symbol | PRR5L |
|---|---|
| Full Name | proline rich 5 like |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 79899 ncbi.nlm.nih.gov/gene/79899 |
| Ensembl ID | ENSG00000185338 |
| UniProt ID | Q6ZMV5 |
| OMIM ID | 617665 |
| HGNC ID | 25890 |
| Aliases | FLJ14213, MGC131831 |
Description
PRR5L (proline rich 5 like) is a protein-coding gene located on chromosome 11p15.5. It encodes a protein that contains proline-rich regions and is involved in cellular processes such as signal transduction and cytoskeletal organization. The gene is expressed in various tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may influence tumor progression | Expression studies in cancer cell lines |
| Colorectal cancer | Potential role in cell proliferation | Gene expression profiling |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Thyroid | 10.1 | Medium |
| Adrenal gland | 8.5 | Low |
| Lung | 6.3 | Low |
| Breast | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Moderate expression |
| HeLa | 9.8 | Moderate expression |
| MCF7 | 7.2 | Low expression |
| A549 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown functional impact |
| c.456G>A | Synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • cytoplasm |
| • nucleus |
Pathways
• Signal Transduction
• Cytoskeletal Signaling
Protein Summary
The PRR5L protein is a proline-rich protein of unknown detailed function. It is predicted to localize to the cytoplasm and nucleus and may participate in protein-protein interactions due to its proline-rich motifs. Expression data suggest roles in testis and thyroid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRR5L Knockout HEK293 Cell Line | EDJ-KQ1193 | Human | 79899 | Details Get a Quote |
| PRR5L Knockout A-549 Cell Line | EDJ-KQ20494 | Human | 79899 | Details Get a Quote |
| PRR5L Knockout HeLa Cell Line | EDJ-KQ20495 | Human | 79899 | Details Get a Quote |
| PRR5L Knockout HCT 116 Cell Line | EDJ-KQ74187 | Human | 79899 | Details Get a Quote |
